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    DUO1 Duo1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852819, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DUO1
    Official Full Name
    Duo1p
    Primary source
    SGD:S000003029
    Locus tag
    YGL061C
    See related
    AllianceGenome:SGD:S000003029; FungiDB:YGL061C; VEuPathDB:YGL061C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to microtubule plus-end binding activity. Involved in attachment of spindle microtubules to kinetochore; positive regulation of attachment of spindle microtubules to kinetochore; and positive regulation of microtubule polymerization. Part of DASH complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DUO1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (388968..389711, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene pseudouridine synthase PUS2 Neighboring gene pyruvate carboxylase 1 Neighboring gene Ybp2p Neighboring gene protein kinase PKP2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation. Kang J, et al. J Cell Biol, 2001 Nov 26. PMID 11724818, Free PMC Article
    2. Exhaustive identification of interaction domains using a high-throughput method based on two-hybrid screening and PCR-convergence: molecular dissection of a kinetochore subunit Spc34p. Ikeuchi A, et al. Nucleic Acids Res, 2003 Dec 1. PMID 14627828, Free PMC Article
    3. Nsl1p is essential for the establishment of bipolarity and the localization of the Dam-Duo complex. Scharfenberger M, et al. EMBO J, 2003 Dec 15. PMID 14657030, Free PMC Article
    4. Saccharomyces cerevisiae Duo1p and Dam1p, novel proteins involved in mitotic spindle function. Hofmann C, et al. J Cell Biol, 1998 Nov 16. PMID 9817759, Free PMC Article
    5. Kinetochore-microtubule error correction is driven by differentially regulated interaction modes. Kalantzaki M, et al. Nat Cell Biol, 2015 Apr. PMID 25751138, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of attachment of spindle microtubules to kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of microtubule polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DASH complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DASH complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of DASH complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Duo1p
    NP_011454.1
    • Essential subunit of the Dam1 complex (aka DASH complex); cooperates with Dam1p and Pse1p to connect the DASH complex with microtubules (MT); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      388968..389711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180926.1 → NP_011454.1  TPA: Duo1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011454.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU80, P53168
      UniProtKB/TrEMBL
      A6ZUB5, C7GRJ7, G2WE35, N1P9R3
      Conserved Domains (1) summary
      pfam08651
      Location:63 → 135
      DASH_Duo1; DASH complex subunit Duo1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53168.1

    Gene LinkOut

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