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    RFX1 Rfx1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850873, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RFX1
    Official Full Name
    Rfx1p
    Primary source
    SGD:S000004166
    Locus tag
    YLR176C
    See related
    AllianceGenome:SGD:S000004166; FungiDB:YLR176C; VEuPathDB:YLR176C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CRT1
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Orthologous to several human genes including RFX2 (regulatory factor X2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RFX1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (507797..510232, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene isocitrate dehydrogenase (NADP(+)) IDP2 Neighboring gene pseudouridine synthase CBF5 Neighboring gene uncharacterized protein Neighboring gene Tfs1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The dimerization/repression domain of RFX1 is related to a conserved region of its yeast homologues Crt1 and Sak1: a new function for an ancient motif. Katan-Khaykovich Y, et al. J Mol Biol, 1999 Nov 19. PMID 10556033
    2. Candida albicans RFX2 encodes a DNA binding protein involved in DNA damage responses, morphogenesis, and virulence. Hao B, et al. Eukaryot Cell, 2009 Apr. PMID 19252121, Free PMC Article
    3. Sen1p contributes to genomic integrity by regulating expression of ribonucleotide reductase 1 (RNR1) in Saccharomyces cerevisiae. Golla U, et al. PLoS One, 2013. PMID 23741394, Free PMC Article
    4. Autorepression of rfx1 gene expression: functional conservation from yeast to humans in response to DNA replication arrest. Lubelsky Y, et al. Mol Cell Biol, 2005 Dec. PMID 16287876, Free PMC Article
    5. Excess histone levels mediate cytotoxicity via multiple mechanisms. Singh RK, et al. Cell Cycle, 2010 Oct 15. PMID 20948314, Free PMC Article

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. two-step activation model of the DNA damage-inducible genes and that Crt1 functions as a signal-dependent dual-transcription activator and repressor that acts in a transient manner
      Title: Molecular genetic analysis of the yeast repressor Rfx1/Crt1 reveals a novel two-step regulatory mechanism.
    2. evidence for a common mechanism for Crt1 and Rfx1 expression and for the conservation of their mode of action in response to a DNA replication block in yeasts and humans
      Title: Autorepression of rfx1 gene expression: functional conservation from yeast to humans in response to DNA replication arrest.
    3. Crt1p may influence deoxyribonucleotide synthesis not only by regulating expression of the ribonucleotide reductase genes but also by modulating dihydrofolate reductase activity
      Title: Identification of new genes regulated by the Crt1 transcription factor, an effector of the DNA damage checkpoint pathway in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Rfx1p
    NP_013277.1
    • Major transcriptional repressor of DNA-damage-regulated genes; recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      507797..510232 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182063.1 → NP_013277.1  TPA: Rfx1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013277.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYI0, P48743
      UniProtKB/TrEMBL
      G2WJ09
      Conserved Domains (1) summary
      pfam02257
      Location:282 → 358
      RFX_DNA_binding; RFX DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48743.2

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