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    SEC21 coatomer subunit gamma [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855429, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SEC21
    Official Full Name
    coatomer subunit gamma
    Primary source
    SGD:S000005231
    Locus tag
    YNL287W
    See related
    AllianceGenome:SGD:S000005231; FungiDB:YNL287W; VEuPathDB:YNL287W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable structural molecule activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Part of COPI vesicle coat. Orthologous to human COPG1 (COPI coat complex subunit gamma 1) and COPG2 (COPI coat complex subunit gamma 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SEC21 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (91994..94801)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene CCR4-NOT core subunit CAF40 Neighboring gene U2 snRNP complex subunit CUS2 Neighboring gene tRNA-Gly

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SEC21 is a gene required for ER to Golgi protein transport that encodes a subunit of a yeast coatomer. Hosobuchi M, et al. Nature, 1992 Dec 10. PMID 1461285
    2. Genome-Wide Screen Reveals sec21 Mutants of Saccharomyces cerevisiae Are Methotrexate-Resistant. Wong LH, et al. G3 (Bethesda), 2017 Apr 3. PMID 28235825, Free PMC Article
    3. COPI-independent anterograde transport: cargo-selective ER to Golgi protein transport in yeast COPI mutants. Gaynor EC, et al. J Cell Biol, 1997 Feb 24. PMID 9049245, Free PMC Article
    4. Full-length structural model of RET3 and SEC21 in COPI: identification of binding sites on the appendage for accessory protein recruitment motifs. Alisaraie L, et al. J Mol Model, 2012 Jul. PMID 22246286, Free PMC Article
    5. Conserved structural motifs in intracellular trafficking pathways: structure of the gammaCOP appendage domain. Hoffman GR, et al. Mol Cell, 2003 Sep. PMID 14527408

    See all (135) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPI vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPI vesicle coat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of COPI vesicle coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in COPI-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coatomer subunit gamma
    NP_014112.1
    • Gamma subunit of coatomer; coatomer is a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      91994..94801
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183125.1 → NP_014112.1  TPA: coatomer subunit gamma [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014112.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0Q6, P32074
      UniProtKB/TrEMBL
      A6ZSJ1, B3LPC5, B5VQD0, C7GS50, C8ZGN4, G2WLI0, N1NZV4
      Conserved Domains (3) summary
      COG5240
      Location:1 → 935
      SEC21; Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]
      sd00044
      Location:416 → 442
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:298 → 334
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32074.2

    Gene LinkOut

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