PUP1 proteasome core particle subunit beta 2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PUP1
Official Full Name: proteasome core particle subunit beta 2
Primary source: SGD:S000005683
Locus tag: YOR157C
See related: AllianceGenome:SGD:S000005683; FungiDB:YOR157C; VEuPathDB:YOR157C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables endopeptidase activity. Involved in proteasomal ubiquitin-independent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in nucleus and proteasome storage granule. Part of proteasome core complex, beta-subunit complex. Human ortholog(s) of this gene implicated in proteosome-associated autoinflammatory syndrome 5. Orthologous to several human genes including PSMB7 (proteasome 20S subunit beta 7). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PUP1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (630966..631751, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables threonine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteasomal ubiquitin-independent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasomal ubiquitin-independent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex, beta-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex, beta-subunit complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex, beta-subunit complex	IEA Inferred from Electronic Annotation more info
located_in proteasome storage granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: proteasome core particle subunit beta 2

NP_014800.3

EC 3.4.25.1

Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

630966..631751 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183576.3 → NP_014800.3 TPA: proteasome core particle subunit beta 2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014800.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2L4, P25043

UniProtKB/TrEMBL

A6ZP01, B3LJI9, B5VS45, C7GN68, C8ZGR5, G2WN29, N1NYI3

Conserved Domains (2) summary

cd03763
Location:30 → 219

proteasome_beta_type_7; proteasome beta type-7 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

pfam12465
Location:223 → 257

Pr_beta_C; Proteasome beta subunits C terminal