Pxmp2 peroxisomal membrane protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pxmp2provided by MGI
Official Full Name: peroxisomal membrane protein 2provided by MGI
Primary source: MGI:MGI:107487
See related: Ensembl:ENSMUSG00000029499 AllianceGenome:MGI:107487
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PMP22
Summary: Located in mitochondrion. Orthologous to human PXMP2 (peroxisomal membrane protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver adult (RPKM 63.7), heart adult (RPKM 27.3) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 53.44 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (110422152..110434036, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (110274286..110286222, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pxmp2 in the mammary fat pad is plays a critical role in stromal lipid homeostasis and in development of mammary gland epithelium in mice
Title: Peroxisomal membrane channel Pxmp2 in the mammary fat pad is essential for stromal lipid homeostasis and for development of mammary gland epithelium in mice.
Pxmp2 channel, with an estimated diameter of 1.4 nm, shows weak cation selectivity and no voltage dependence. The long-lasting open states of the channel indicate its functional role as a protein forming a general diffusion pore in the membrane
Title: Pxmp2 is a channel-forming protein in Mammalian peroxisomal membrane.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1) 1 citation

General gene information

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Markers

Pxmp2 (e-PCR), detects polymorphism
- UniSTS:233943

Gene Ontology Provided by MGI

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal membrane	ISO Inferred from Sequence Orthology more info
located_in peroxisomal membrane	TAS Traceable Author Statement more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peroxisomal membrane protein 2

Names: 22 kDa peroxisomal membrane protein; peroxisomal membrane protein 2, 22 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001405245.1 → NP_001392174.1 peroxisomal membrane protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC118260
NM_008993.3 → NP_033019.2 peroxisomal membrane protein 2 isoform 1

See identical proteins and their annotated locations for NP_033019.2

Status: VALIDATED

Source sequence(s)

AC118260

Consensus CDS

CCDS19524.1

UniProtKB/Swiss-Prot

P42925, Q9ERF1

UniProtKB/TrEMBL

Q5D073

Related

ENSMUSP00000031472.6, ENSMUST00000031472.12

Conserved Domains (1) summary

pfam04117
Location:129 → 191

Mpv17_PMP22; Mpv17 / PMP22 family

RNA

NR_175919.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC118260

Related

ENSMUST00000155266.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

110422152..110434036 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164916.1 → XP_036020809.1 peroxisomal membrane protein 2 isoform X2

Conserved Domains (1) summary

pfam04117
Location:37 → 98

Mpv17_PMP22; Mpv17 / PMP22 family