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    Myh6 myosin heavy chain 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29556, updated on 3-Dec-2024

    Summary

    Official Symbol
    Myh6provided by RGD
    Official Full Name
    myosin heavy chain 6provided by RGD
    Primary source
    RGD:62029
    See related
    EnsemblRapid:ENSRNOG00000025757 AllianceGenome:RGD:62029
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Myh7; Myhca; Myosin-7; MyHC-beta; MyHC-slow
    Summary
    Enables several functions, including ATP binding activity; calcium-dependent ATPase activity; and identical protein binding activity. Involved in cellular response to 3,3',5-triiodo-L-thyronine and muscle contraction. Located in myofibril. Part of muscle myosin complex. Biomarker of congestive heart failure; hypothyroidism; and myocardial infarction. Human ortholog(s) of this gene implicated in atrial heart septal defect (multiple); heart conduction disease (multiple); and intrinsic cardiomyopathy (multiple). Orthologous to human MYH6 (myosin heavy chain 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 38771.4) See more
    Orthologs
    NEW
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    Genomic context

    See Myh6 in Genome Data Viewer
    Location:
    15p13
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (32388102..32413663, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (28418120..28442316, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (33605653..33629730, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene interleukin 25 Neighboring gene CKLF-like MARVEL transmembrane domain containing 5 Neighboring gene uncharacterized LOC108352923 Neighboring gene microRNA 3546 Neighboring gene microRNA 208a Neighboring gene uncharacterized LOC120096985 Neighboring gene myosin heavy chain 7 Neighboring gene microRNA 208b Neighboring gene uncharacterized LOC120096984

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-dependent ATPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microfilament motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables microfilament motor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables microfilament motor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within actin filament-based movement ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adult heart development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within adult heart development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adult heart development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in atrial cardiac muscle tissue morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in atrial cardiac muscle tissue morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle cell development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle hypertrophy in response to stress IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to 3,3',5-triiodo-L-thyronine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in muscle filament sliding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in muscle filament sliding ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within myofibril assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of ATP-dependent activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of heart growth IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of heart growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of heart rate IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of the force of heart contraction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of the force of heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of the force of heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sarcomere organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within sarcomere organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within striated muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in striated muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ventricular cardiac muscle tissue morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ventricular cardiac muscle tissue morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in visceral muscle development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within visceral muscle development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of muscle myosin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in myofibril IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in myofibril IEA
    Inferred from Electronic Annotation
    more info
     
    located_in myofibril ISO
    Inferred from Sequence Orthology
    more info
     
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of myosin complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in myosin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in myosin filament IEA
    Inferred from Electronic Annotation
    more info
     
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
     
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    myosin-6
    Names
    Myosin heavy chain 7
    myHC-alpha
    myosin heavy chain polypeptide 6 cardiac muscle adult
    myosin heavy chain, polypeptide 6, cardiac muscle, alpha
    myosin, heavy chain 6, cardiac muscle, alpha
    myosin, heavy polypeptide 6, cardiac muscle, alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017239.2NP_058935.2  myosin-6

      See identical proteins and their annotated locations for NP_058935.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      P02563, Q63351
      UniProtKB/TrEMBL
      A6KGY0
      Related
      ENSRNOP00000023301.3, ENSRNOT00000023302.4
      Conserved Domains (3) summary
      cd01377
      Location:99768
      MYSc_class_II; class II myosins, motor domain
      pfam01576
      Location:8481925
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3472
      Myosin_N; Myosin N-terminal SH3-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      32388102..32413663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274186.1XP_063130256.1  myosin-6 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A2T6, G3V885
    2. XM_017599641.3XP_017455130.1  myosin-6 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A2T6, G3V885
    3. XM_039093219.2XP_038949147.1  myosin-6 isoform X1

      UniProtKB/Swiss-Prot
      P02563, Q63351
      UniProtKB/TrEMBL
      A6KGY0
      Conserved Domains (3) summary
      cd01377
      Location:99768
      MYSc_class_II; class II myosins, motor domain
      pfam01576
      Location:8481925
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3472
      Myosin_N; Myosin N-terminal SH3-like domain
    4. XM_063274185.1XP_063130255.1  myosin-6 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A2T6, G3V885
    5. XM_063274184.1XP_063130254.1  myosin-6 isoform X1

      UniProtKB/Swiss-Prot
      P02563, Q63351
      UniProtKB/TrEMBL
      A6KGY0