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    Egln2 egl-9 family hypoxia-inducible factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308457, updated on 27-Nov-2024

    Summary

    Official Symbol
    Egln2provided by RGD
    Official Full Name
    egl-9 family hypoxia-inducible factor 2provided by RGD
    Primary source
    RGD:631376
    See related
    EnsemblRapid:ENSRNOG00000020947 AllianceGenome:RGD:631376
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PHD1; HPH-1; HPH-3; PHD-1; HIF-PH1
    Summary
    Enables peptidyl-proline 4-dioxygenase activity. Involved in peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human EGLN2 (egl-9 family hypoxia inducible factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 213.7), Testes (RPKM 198.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Egln2 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (91579205..91586985, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (82451554..82459809, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (83969456..83977665, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene phosphoglycerate kinase 1, pseudogene 6 Neighboring gene cytochrome P450, family 2, subfamily f, polypeptide 4 Neighboring gene cytochrome P450, family 2, subfamily t, polypeptide 1 Neighboring gene RAB4B, member RAS oncogene family Neighboring gene MIA SH3 domain containing

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC93662, MGC93666

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2-oxoglutarate-dependent dioxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ferrous iron binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ferrous iron binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ferrous iron binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables hypoxia-inducible factor-proline dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxygen sensor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxygen sensor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidyl-proline 4-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptidyl-proline 4-dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidyl-proline 4-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidyl-proline 4-dioxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell redox homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    prolyl hydroxylase EGLN2
    Names
    HIF-1alpha prolyl-4-hydroxylase-1
    HIF-prolyl hydroxylase 1
    hypoxia-inducible factor prolyl hydroxylase 1
    prolyl hydroxylase domain-containing protein 1
    NP_001004083.1
    XP_038967457.1
    XP_038967464.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004083.1NP_001004083.1  prolyl hydroxylase EGLN2

      See identical proteins and their annotated locations for NP_001004083.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078907
      UniProtKB/Swiss-Prot
      Q6AYU4
      Related
      ENSRNOP00000028434.4, ENSRNOT00000028434.8
      Conserved Domains (1) summary
      smart00702
      Location:213383
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      91579205..91586985 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111529.2XP_038967457.1  prolyl hydroxylase EGLN2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZS56
      Related
      ENSRNOP00000081509.1, ENSRNOT00000116136.2
      Conserved Domains (1) summary
      smart00702
      Location:329438
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    2. XM_039111536.1XP_038967464.1  prolyl hydroxylase EGLN2 isoform X2

      UniProtKB/TrEMBL
      A6J9B3
      Conserved Domains (1) summary
      smart00702
      Location:397
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues