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    Kcnc2 potassium voltage-gated channel subfamily C member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246153, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kcnc2provided by RGD
    Official Full Name
    potassium voltage-gated channel subfamily C member 2provided by RGD
    Primary source
    RGD:628829
    See related
    EnsemblRapid:ENSRNOG00000004077 AllianceGenome:RGD:628829
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kv3.2; KShIIIA
    Summary
    Enables delayed rectifier potassium channel activity; transmembrane transporter binding activity; and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Involved in several processes, including cellular response to nitric oxide; nervous system development; and protein complex oligomerization. Located in several cellular components, including axon; basolateral plasma membrane; and neuronal cell body membrane. Part of voltage-gated potassium channel complex. Is active in GABA-ergic synapse and presynaptic membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 103. Orthologous to human KCNC2 (potassium voltage-gated channel subfamily C member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 187.0) and Adrenal (RPKM 92.0) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Kcnc2 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (49586274..49770212)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (47700035..47883979)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (54978453..55159362)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene calcyphosine 2 Neighboring gene ribosomal protein L27a, pseudogene 2 Neighboring gene uncharacterized LOC134479688 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to ammonium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to nitric oxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in globus pallidus development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in membrane hyperpolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane hyperpolarization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in monoatomic ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nitric oxide-cGMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in optic nerve development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in positive regulation of potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of voltage-gated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein heterooligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of action potential firing rate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of action potential firing rate ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of presynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to amine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to light intensity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to magnesium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to nerve growth factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in axon terminus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dendrite membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuronal cell body membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    voltage-gated potassium channel KCNC2; potassium voltage-gated channel subfamily C member 2
    Names
    potassium channel voltage-gated Shaw-related subfamily C member 2
    potassium voltage gated channel, Shaw-related subfamily, member 2
    shaw-like potassium channel
    voltage-gated potassium channel subunit Kv3.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139216.1NP_631962.1  voltage-gated potassium channel KCNC2 isoform a

      See identical proteins and their annotated locations for NP_631962.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (a) includes alternate penultimate exons, compared to variant b, resulting in a novel 3' coding region and longer 3' UTR. It encodes isoform a which has a distinct C-terminus, compared to isoform b.
      Source sequence(s)
      M34052
      UniProtKB/TrEMBL
      A6IGI6, A6IGJ0
      Conserved Domains (2) summary
      cd18415
      Location:7166
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:228484
      Ion_trans; Ion transport protein
    2. NM_139217.1NP_631963.1  voltage-gated potassium channel KCNC2 isoform b

      See identical proteins and their annotated locations for NP_631963.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (b) encodes the longer isoform (b).
      Source sequence(s)
      M59211
      UniProtKB/Swiss-Prot
      P22461, P22462, P22463, Q63735
      UniProtKB/TrEMBL
      A6IGI6, A6IGJ3
      Conserved Domains (4) summary
      smart00225
      Location:10159
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:277484
      Ion_trans; Ion transport protein
      pfam02214
      Location:10151
      BTB_2; BTB/POZ domain
      pfam07885
      Location:427474
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      49586274..49770212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078413.2XP_038934341.1  potassium voltage-gated channel subfamily C member 2 isoform X5

      UniProtKB/TrEMBL
      A6IGI6, A6IGJ4
      Conserved Domains (2) summary
      cd18415
      Location:7166
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:228484
      Ion_trans; Ion transport protein
    2. XM_039078416.2XP_038934344.1  potassium voltage-gated channel subfamily C member 2 isoform X5

      UniProtKB/TrEMBL
      A6IGI6, A6IGJ4
      Conserved Domains (2) summary
      cd18415
      Location:7166
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:228484
      Ion_trans; Ion transport protein
    3. XM_017594661.3XP_017450150.1  potassium voltage-gated channel subfamily C member 2 isoform X2

      UniProtKB/TrEMBL
      A6IGI6
      Related
      ENSRNOP00000084708.1, ENSRNOT00000099049.2
    4. XM_006241327.5XP_006241389.1  potassium voltage-gated channel subfamily C member 2 isoform X1

      See identical proteins and their annotated locations for XP_006241389.1

      UniProtKB/Swiss-Prot
      P22461, P22462, P22463, Q63735
      UniProtKB/TrEMBL
      A6IGI6, A6IGJ3
      Conserved Domains (4) summary
      smart00225
      Location:10159
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:277484
      Ion_trans; Ion transport protein
      pfam02214
      Location:10151
      BTB_2; BTB/POZ domain
      pfam07885
      Location:427474
      Ion_trans_2; Ion channel
    5. XM_039078411.2XP_038934339.1  potassium voltage-gated channel subfamily C member 2 isoform X4

      UniProtKB/TrEMBL
      A6IGI6, A6IGJ0
      Related
      ENSRNOP00000005690.2, ENSRNOT00000005690.6
      Conserved Domains (2) summary
      cd18415
      Location:7166
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:228484
      Ion_trans; Ion transport protein
    6. XM_017594662.3XP_017450151.1  potassium voltage-gated channel subfamily C member 2 isoform X3

      UniProtKB/TrEMBL
      A6IGI6, A6IGI7
      Conserved Domains (4) summary
      smart00225
      Location:10159
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:277484
      Ion_trans; Ion transport protein
      pfam02214
      Location:10151
      BTB_2; BTB/POZ domain
      pfam07885
      Location:427474
      Ion_trans_2; Ion channel
    7. XM_039078412.2XP_038934340.1  potassium voltage-gated channel subfamily C member 2 isoform X5

      UniProtKB/TrEMBL
      A6IGI6, A6IGJ4
      Related
      ENSRNOP00000005773.5, ENSRNOT00000005773.9
      Conserved Domains (2) summary
      cd18415
      Location:7166
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:228484
      Ion_trans; Ion transport protein
    8. XM_017594660.3XP_017450149.1  potassium voltage-gated channel subfamily C member 2 isoform X1

      UniProtKB/Swiss-Prot
      P22461, P22462, P22463, Q63735
      UniProtKB/TrEMBL
      A6IGI6, A6IGJ3

    RNA

    1. XR_005486545.2 RNA Sequence