Trhde thyrotropin-releasing hormone degrading enzyme [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trhdeprovided by RGD
Official Full Name: thyrotropin-releasing hormone degrading enzymeprovided by RGD
Primary source: RGD:728895
See related: EnsemblRapid:ENSRNOG00000005278 AllianceGenome:RGD:728895
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PAP-II
Summary: Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. Orthologous to human TRHDE (thyrotropin releasing hormone degrading enzyme). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 61.8), Lung (RPKM 24.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (51829473..52236843, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (49943271..50350613, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (57253023..57679795, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Delayed increases in both the median eminence PPII as well as the thyroliberinase activities in fasted male rats may facilitate the maintenance of deep downregulation of the HPT axis function, despite a partial reactivation of TRH expression in the PVN.
Title: Fasting Enhances Pyroglutamyl Peptidase II Activity in Tanycytes of the Mediobasal Hypothalamus of Male Adult Rats.
Twenty to 35% of Pyroglutamyl peptidase II mRNA-labeled profiles were positive for TRH-receptor 1 (TRH-R1) mRNA.
Title: Pyroglutamyl peptidase II inhibition enhances the analeptic effect of thyrotropin-releasing hormone in the rat medial septum.
Food-restricted and dehydrated-induced anorexic rats present differential TRH expression in anterior and caudal PVN. Role of type 2 deiodinase and pyroglutamyl aminopeptidase II.
Title: Food-restricted and dehydrated-induced anorexic rats present differential TRH expression in anterior and caudal PVN. Role of type 2 deiodinase and pyroglutamyl aminopeptidase II.
PAP-I and PAP-II expression was induced by the decreased dopamine levels in the intermediate lobe of the pituitary under continuous stress.
Title: Continuous stress-induced dopamine dysregulation augments PAP-I and PAP-II expression in melanotrophs of the pituitary gland.
An increase in circulating thyroid hormone up-regulates PPII activity in tanycytes and enhances degradation of extracellular TRH in the median eminence through glial-axonal associations.
Title: Tanycyte pyroglutamyl peptidase II contributes to regulation of the hypothalamic-pituitary-thyroid axis through glial-axonal associations in the median eminence.
shortening of side chain at PPII-269 position is required for adjustment to thepyroglutamyl residue
Title: Homology modeling and site-directed mutagenesis of pyroglutamyl peptidase II. Insights into omega-versus aminopeptidase specificity in the M1 family.

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General gene information

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Markers

D7Wox33 (e-PCR)
- UniSTS:239379

RH131058 (e-PCR)
- UniSTS:214341

BI302213 (e-PCR)
- UniSTS:247625

RH144062 (e-PCR)
- UniSTS:233308

D7Got80 (e-PCR)
- UniSTS:113845

RH141425 (e-PCR)
- UniSTS:223419

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables aminopeptidase activity	TAS Traceable Author Statement more info	PubMed
enables metalloaminopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables pyroglutamyl-peptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in peptide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thyrotropin-releasing hormone-degrading ectoenzyme

Names: TRH-DE; TRH-degrading ectoenzyme; TRH-specific aminopeptidase; pyroglutamyl-peptidase II; thyroliberinase

NP_001102461.1

EC 3.4.19.6

XP_038935612.1

EC 3.4.19.6

XP_038935613.1

EC 3.4.19.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108991.2 → NP_001102461.1 thyrotropin-releasing hormone-degrading ectoenzyme

See identical proteins and their annotated locations for NP_001102461.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

G3V6Q2, Q10836

UniProtKB/TrEMBL

A0A8I5ZM45, A6IGK0

Related

ENSRNOP00000007461.4, ENSRNOT00000007461.7

Conserved Domains (2) summary

cd09601
Location:190 → 635

M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)

pfam11838
Location:720 → 1044

ERAP1_C; ERAP1-like C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

51829473..52236843 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039079684.2 → XP_038935612.1 thyrotropin-releasing hormone-degrading ectoenzyme isoform X1

UniProtKB/TrEMBL

A0A8I5ZM45

Related

ENSRNOP00000111942.1, ENSRNOT00000163342.1

Conserved Domains (2) summary

cd09601
Location:190 → 589

M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)

pfam11838
Location:674 → 998

ERAP1_C; ERAP1-like C-terminal domain
XM_039079685.2 → XP_038935613.1 thyrotropin-releasing hormone-degrading ectoenzyme isoform X2

Conserved Domains (1) summary

cd09601
Location:190 → 571

M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)