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    Carmil3 capping protein regulator and myosin 1 linker 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361041, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Carmil3provided by RGD
    Official Full Name
    capping protein regulator and myosin 1 linker 3provided by RGD
    Primary source
    RGD:1359120
    See related
    EnsemblRapid:ENSRNOG00000025518 AllianceGenome:RGD:1359120
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lrrc16b
    Summary
    Predicted to be involved in cell migration; regulation of Arp2/3 complex-mediated actin nucleation; and regulation of postsynapse assembly. Predicted to be located in cytoplasm. Predicted to be active in several cellular components, including glutamatergic synapse; lamellipodium; and postsynapse. Orthologous to human CARMIL3 (capping protein regulator and myosin 1 linker 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 41.2), Heart (RPKM 25.4) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Carmil3 in Genome Data Viewer
    Location:
    15p13
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (32948228..32965829)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (28978440..28995865)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34167146..34184799)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S17, pseudogene 8 Neighboring gene dehydrogenase/reductase 4 Neighboring gene uncharacterized LOC102552093 Neighboring gene copine 6 Neighboring gene neural retina leucine zipper

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cell Migration and Invadopodia Formation Require a Membrane-binding Domain of CARMIL2. Lanier MH, et al. J Biol Chem, 2016 Jan 15. PMID 26578515, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynapse assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    capping protein, Arp2/3 and myosin-I linker protein 3
    Names
    capping protein regulator and myosin 1 linker protein 3
    leucine rich repeat containing 16B
    leucine-rich repeat-containing protein 16B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014138.3 → NP_001014160.2  capping protein, Arp2/3 and myosin-I linker protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A0H2UHV1
      Conserved Domains (4) summary
      cd00116
      Location:339 → 600
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:275 → 303
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:245 → 273
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:778 → 1062
      CARMIL_C; CARMIL C-terminus

    2. NM_001431678.1 → NP_001418607.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015

    3. NM_001431679.1 → NP_001418608.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015

    4. NM_001431680.1 → NP_001418609.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      32948228..32965829
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008770681.4 → XP_008768903.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X1

      Related
      ENSRNOP00000036263.7, ENSRNOT00000032252.7
      Conserved Domains (4) summary
      cd00116
      Location:339 → 600
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:275 → 303
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:245 → 273
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:778 → 1062
      CARMIL_C; CARMIL C-terminus

    2. XM_008770682.4 → XP_008768904.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A0H2UHV1
      Conserved Domains (4) summary
      cd00116
      Location:339 → 600
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:275 → 303
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:245 → 273
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:778 → 1062
      CARMIL_C; CARMIL C-terminus

    3. XM_008770683.4 → XP_008768905.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X3

      Conserved Domains (4) summary
      cd00116
      Location:339 → 600
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:275 → 303
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:245 → 273
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:778 → 1062
      CARMIL_C; CARMIL C-terminus

    4. XM_063274405.1 → XP_063130475.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X5

    5. XM_063274404.1 → XP_063130474.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X4

    6. XM_008770684.4 → XP_008768906.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X6

      Conserved Domains (4) summary
      cd00116
      Location:339 → 600
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:275 → 303
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:245 → 273
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:778 → 1062
      CARMIL_C; CARMIL C-terminus

    7. XM_008770685.4 → XP_008768907.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X7

      See identical proteins and their annotated locations for XP_008768907.1

      UniProtKB/Swiss-Prot
      Q5XHY1
      UniProtKB/TrEMBL
      A0A0H2UHV1
      Conserved Domains (4) summary
      cd00116
      Location:339 → 600
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:275 → 303
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:245 → 273
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:778 → 1062
      CARMIL_C; CARMIL C-terminus

    8. XM_063274406.1 → XP_063130476.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X8

    9. XM_008770687.4 → XP_008768909.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X9

      UniProtKB/TrEMBL
      A0A0H2UHV1
      Conserved Domains (4) summary
      cd00116
      Location:246 → 507
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:182 → 210
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:152 → 180
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:685 → 969
      CARMIL_C; CARMIL C-terminus

    10. XM_039093487.2 → XP_038949415.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X10

      Conserved Domains (1) summary
      pfam16000
      Location:198 → 482
      CARMIL_C; CARMIL C-terminus

    11. XM_039093488.2 → XP_038949416.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X11

      Conserved Domains (1) summary
      pfam16000
      Location:110 → 394
      CARMIL_C; CARMIL C-terminus

    RNA

    1. XR_005493761.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XHY1.2 GenPept UniProtKB/Swiss-Prot:Q5XHY1

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