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    Ric8a RIC8 guanine nucleotide exchange factor A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293614, updated on 7-Dec-2024

    Summary

    Official Symbol
    Ric8aprovided by RGD
    Official Full Name
    RIC8 guanine nucleotide exchange factor Aprovided by RGD
    Primary source
    RGD:727957
    See related
    EnsemblRapid:ENSRNOG00000013256 AllianceGenome:RGD:727957
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ric8; Ric-8A
    Summary
    Enables G-protein alpha-subunit binding activity; GTPase regulator activity; and protein folding chaperone. Involved in G protein-coupled receptor signaling pathway. Located in cytoplasm and plasma membrane. Orthologous to human RIC8A (RIC8 guanine nucleotide exchange factor A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 187.0), Adrenal (RPKM 176.1) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ric8a in Genome Data Viewer
    Location:
    1q41
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (205364796..205371102)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (195935162..195941469)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (213606599..213612905)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene Sec61 translocon subunit gamma, pseudogene 3 Neighboring gene secretoglobin, family 1C, member 1 Neighboring gene ciliary microtubule associated protein 1A Neighboring gene Bet1 golgi vesicular membrane trafficking protein-like Neighboring gene sirtuin 3 Neighboring gene proteasome 26S subunit, non-ATPase 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G-protein alpha-subunit binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G-protein alpha-subunit binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein folding chaperone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein folding chaperone ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    chaperone Ric-8A; synembryn-A
    Names
    heterotrimeric G protein guanine nucleotide exchange factor Ric-8A
    resistance to inhibitors of cholinesterase 8 homolog
    resistance to inhibitors of cholinesterase 8A
    resistance to inhibitors of cholinesterase 8A-like protein
    synembryn

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100520.1NP_001093990.1  chaperone Ric-8A

      See identical proteins and their annotated locations for NP_001093990.1

      Status: PROVISIONAL

      Source sequence(s)
      BC160852
      UniProtKB/Swiss-Prot
      B1H241, Q80ZG1
      UniProtKB/TrEMBL
      A0A1L1WKK3, F7F506
      Related
      ENSRNOP00000018470.4, ENSRNOT00000018470.7
      Conserved Domains (1) summary
      pfam10165
      Location:67497
      Ric8; Guanine nucleotide exchange factor synembryn

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      205364796..205371102
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107824.2XP_038963752.1  synembryn-A isoform X1

      Conserved Domains (1) summary
      pfam10165
      Location:2381
      Ric8; Guanine nucleotide exchange factor synembryn