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    Klf1 KLF transcription factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304666, updated on 9-Dec-2024

    Summary

    Official Symbol
    Klf1provided by RGD
    Official Full Name
    KLF transcription factor 1provided by RGD
    Primary source
    RGD:1309398
    See related
    EnsemblRapid:ENSRNOG00000003443 AllianceGenome:RGD:1309398
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and ubiquitin binding activity. Involved in cellular response to peptide and maternal process involved in female pregnancy. Predicted to be located in chromatin and nucleoplasm. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type IV. Orthologous to human KLF1 (KLF transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 271.7) and Lung (RPKM 11.0) See more
    Orthologs
    NEW
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    Genomic context

    See Klf1 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (40155476..40158651, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (23250627..23253802, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (26016289..26019557)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene microtubule associated serine/threonine kinase 1 Neighboring gene microRNA 3550 Neighboring gene deoxyribonuclease 2, lysosomal Neighboring gene glutaryl-CoA dehydrogenase Neighboring gene synaptonemal complex central element protein 2 Neighboring gene phenylalanyl-tRNA synthetase subunit alpha

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cellular response to peptide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within erythrocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within erythrocyte maturation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within liver development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in maternal process involved in female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    Krueppel-like factor 1
    Names
    Kruppel like factor 1
    Kruppel-like factor 1 (erythroid)
    erythroid Kruppel-like factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107164.1NP_001100634.1  Krueppel-like factor 1

      See identical proteins and their annotated locations for NP_001100634.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473972
      UniProtKB/TrEMBL
      A6IY63, B0BNN2
      Related
      ENSRNOP00000004601.6, ENSRNOT00000004601.7
      Conserved Domains (6) summary
      COG5048
      Location:297375
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:298317
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:293317
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:339364
      zf-H2C2_2; Zinc-finger double domain
      pfam16832
      Location:4065
      EKLF_TAD1; Erythroid krueppel-like transcription factor, transactivation 1
      pfam16833
      Location:81103
      EKLF_TAD2; Erythroid krueppel-like transcription factor, transactivation 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      40155476..40158651 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255254.5XP_006255316.1  Krueppel-like factor 1 isoform X1

      UniProtKB/TrEMBL
      B0BNN2
      Conserved Domains (6) summary
      COG5048
      Location:297380
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:298317
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:293317
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:344369
      zf-H2C2_2; Zinc-finger double domain
      pfam16832
      Location:4065
      EKLF_TAD1; Erythroid krueppel-like transcription factor, transactivation 1
      pfam16833
      Location:81103
      EKLF_TAD2; Erythroid krueppel-like transcription factor, transactivation 2