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    Gnmt glycine N-methyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25134, updated on 27-Nov-2024

    Summary

    Symbol
    Gnmtprovided by RGD
    Full Name
    glycine N-methyltransferaseprovided by RGD
    Primary source
    RGD:2719
    See related
    EnsemblRapid:ENSRNOG00000016349 AllianceGenome:RGD:2719
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables several functions, including S-adenosyl-L-methionine binding activity; carboxylic acid binding activity; and glycine N-methyltransferase activity. Involved in several processes, including S-adenosylmethionine metabolic process; alpha-amino acid metabolic process; and protein homotetramerization. Located in cytosol. Part of methyltransferase complex. Human ortholog(s) of this gene implicated in glycine N-methyltransferase deficiency. Orthologous to human GNMT (glycine N-methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 2226.4) See more
    Orthologs
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    Genomic context

    See Gnmt in Genome Data Viewer
    Location:
    9q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (21752235..21756368)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (14254675..14258028)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (16565274..16568626)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene pre T-cell antigen receptor alpha Neighboring gene canopy FGF signaling regulator 3 Neighboring gene peroxisomal biogenesis factor 6 Neighboring gene protein phosphatase 2, regulatory subunit B', delta Neighboring gene kelch domain containing 3 Neighboring gene male-enhanced antigen 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables S-adenosyl-L-methionine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables S-adenosyl-L-methionine binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables S-adenosylmethionine-dependent methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables folic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables folic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables folic acid binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables glycine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glycine N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glycine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables glycine N-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables glycine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glycine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glycine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glycine binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables glycine binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables glycine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glycine binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables identical protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables selenol Se-methyltransferase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in S-adenosylhomocysteine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in S-adenosylhomocysteine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in S-adenosylhomocysteine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in S-adenosylmethionine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in S-adenosylmethionine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in S-adenosylmethionine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in S-adenosylmethionine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in S-adenosylmethionine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glycogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within methionine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in one-carbon metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within one-carbon metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homotetramerization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein homotetramerization IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sarcosine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sarcosine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of methyltransferase complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    glycine N-methyltransferase
    Names
    folate-binding protein
    glycine methyltransferase
    NP_058780.1
    XP_063122731.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017084.1NP_058780.1  glycine N-methyltransferase

      See identical proteins and their annotated locations for NP_058780.1

      Status: PROVISIONAL

      Source sequence(s)
      X06150
      UniProtKB/Swiss-Prot
      P13255
      UniProtKB/TrEMBL
      A6JIM7
      Related
      ENSRNOP00000022307.3, ENSRNOT00000022307.6
      Conserved Domains (1) summary
      pfam13649
      Location:61169
      Methyltransf_25; Methyltransferase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      21752235..21756368
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266661.1XP_063122731.1  glycine N-methyltransferase isoform X1

      UniProtKB/TrEMBL
      M0RDH0
      Related
      ENSRNOP00000067671.2, ENSRNOT00000072812.3