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    Dnph1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171047, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dnph1provided by RGD
    Official Full Name
    2'-deoxynucleoside 5'-phosphate N-hydrolase 1provided by RGD
    Primary source
    RGD:620382
    See related
    EnsemblRapid:ENSRNOG00000018397 AllianceGenome:RGD:620382
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rcl; C6orf108; RGD620382
    Summary
    Enables deoxyribonucleoside 5'-monophosphate N-glycosidase activity and protein homodimerization activity. Involved in allantoin metabolic process; dGMP catabolic process; and positive regulation of cell growth. Located in nucleus. Orthologous to human DNPH1 (2'-deoxynucleoside 5'-phosphate N-hydrolase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 59.0), Spleen (RPKM 40.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Dnph1 in Genome Data Viewer
    Location:
    9q12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (21978894..21981631, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (14481296..14484034, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (16845764..16848514, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene serum response factor Neighboring gene cullin 9 Neighboring gene tau tubulin kinase 1 Neighboring gene solute carrier family 22 member 7 Neighboring gene cysteine-rich protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 5-hydroxymethyl-dUMP N-hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 5-hydroxymethyl-dUMP N-hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 5-hydroxymethyl-dUMP N-hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 5-hydroxymethyl-dUMP N-hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    5-hydroxymethyl-dUMP N-hydrolase
    Names
    Nucleoside 2-deoxyribosyltransferase domain containing protein RGD620382
    c-Myc-responsive protein Rcl
    deoxyribonucleoside 5'-monophosphate N-glycosidase
    putative c-Myc-responsive
    NP_598209.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133525.2NP_598209.1  5-hydroxymethyl-dUMP N-hydrolase

      See identical proteins and their annotated locations for NP_598209.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      O35820
      UniProtKB/TrEMBL
      A6JIQ6
      Related
      ENSRNOP00000024815.5, ENSRNOT00000024815.8
      Conserved Domains (1) summary
      pfam05014
      Location:12115
      Nuc_deoxyrib_tr; Nucleoside 2-deoxyribosyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      21978894..21981631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)