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    Efs embryonal Fyn-associated substrate [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290212, updated on 27-Nov-2024

    Summary

    Official Symbol
    Efsprovided by RGD
    Official Full Name
    embryonal Fyn-associated substrateprovided by RGD
    Primary source
    RGD:1308966
    See related
    EnsemblRapid:ENSRNOG00000042029 AllianceGenome:RGD:1308966
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable SH3 domain binding activity. Predicted to be involved in cell migration and cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be active in cytoplasm and focal adhesion. Predicted to colocalize with plasma membrane. Orthologous to human EFS (embryonal Fyn-associated substrate). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Uterus (RPKM 41.7), Lung (RPKM 33.3) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Efs in Genome Data Viewer
    Location:
    15p13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (32362401..32374490, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (28392417..28403016, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (33579952..33590217, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene poly(A) binding protein, nuclear 1 Neighboring gene solute carrier family 22, member 17 Neighboring gene interleukin 25 Neighboring gene CKLF-like MARVEL transmembrane domain containing 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    embryonal Fyn-associated substrate

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106033.2NP_001099503.1  embryonal Fyn-associated substrate

      See identical proteins and their annotated locations for NP_001099503.1

      Status: PROVISIONAL

      Source sequence(s)
      BC161942
      UniProtKB/TrEMBL
      A0A8I6ANS3, B1WBZ1
      Related
      ENSRNOP00000022514.5, ENSRNOT00000022514.7
      Conserved Domains (2) summary
      cd12003
      Location:870
      SH3_EFS; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member, Embryonal Fyn-associated Substrate
      pfam12026
      Location:372556
      DUF3513; Domain of unknown function (DUF3513)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      32362401..32374490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017599619.3XP_017455108.1  embryonal Fyn-associated substrate isoform X1

      UniProtKB/TrEMBL
      A0A8I6ANS3, F7F497
      Related
      ENSRNOP00000098664.1, ENSRNOT00000128686.1