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    Csrp2 cysteine and glycine-rich protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29317, updated on 27-Nov-2024

    Summary

    Official Symbol
    Csrp2provided by RGD
    Official Full Name
    cysteine and glycine-rich protein 2provided by RGD
    Primary source
    RGD:61950
    See related
    EnsemblRapid:ENSRNOG00000003772 AllianceGenome:RGD:61950
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SmLIM
    Summary
    Predicted to enable actinin binding activity. Predicted to be a structural constituent of muscle. Involved in myoblast differentiation. Predicted to be active in Z disc and nucleus. Orthologous to human CSRP2 (cysteine and glycine rich protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 647.5), Thymus (RPKM 491.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Csrp2 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (48235415..48254049)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (46349109..46367743)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (53630675..53649309)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479685 Neighboring gene U6 spliceosomal RNA Neighboring gene zinc finger DHHC-type palmitoyltransferase 17 Neighboring gene uncharacterized LOC120093583 Neighboring gene pescadillo ribosomal biogenesis factor 1, pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actinin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of muscle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in muscle tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in myoblast differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cysteine and glycine-rich protein 2
    Names
    CRP2
    LIM/double zinc-finger protein
    cysteine-rich protein 2
    smooth muscle cell LIM protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177425.3NP_803174.2  cysteine and glycine-rich protein 2

      See identical proteins and their annotated locations for NP_803174.2

      Status: VALIDATED

      Source sequence(s)
      CD373038, U44948
      UniProtKB/Swiss-Prot
      Q62908
      UniProtKB/TrEMBL
      A6IGF2
      Related
      ENSRNOP00000075692.2, ENSRNOT00000080598.3
      Conserved Domains (2) summary
      cd09480
      Location:963
      LIM1_CRP2; The first LIM domain of Cysteine Rich Protein 2 (CRP2)
      cd09840
      Location:119172
      LIM2_CRP2; The second LIM domain of Cysteine Rich Protein 2 (CRP2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      48235415..48254049
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)