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    Gng2 G protein subunit gamma 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 80850, updated on 27-Nov-2024

    Summary

    Official Symbol
    Gng2provided by RGD
    Official Full Name
    G protein subunit gamma 2provided by RGD
    Primary source
    RGD:69268
    See related
    EnsemblRapid:ENSRNOG00000048980 AllianceGenome:RGD:69268
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable G-protein beta-subunit binding activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and fibroblast proliferation. Part of heterotrimeric G-protein complex. Orthologous to human GNG2 (G protein subunit gamma 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 274.5), Spleen (RPKM 92.1) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gng2 in Genome Data Viewer
    Location:
    15p16
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (4365222..4466060)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (4316038..4416918)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (4748242..4853555)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene SAYSVFN motif domain containing 1 Neighboring gene uncharacterized LOC134481915 Neighboring gene uncharacterized LOC102554918 Neighboring gene RNA transcription, translation and transport factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of heterotrimeric G-protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of heterotrimeric G-protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Names
    guanine nucleotide binding protein (G protein), gamma 2 subunit
    NP_001244278.1
    NP_113942.1
    XP_038949608.1
    XP_038949609.1
    XP_038949610.1
    XP_063130760.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001257349.1NP_001244278.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

      See identical proteins and their annotated locations for NP_001244278.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6KKL4
      Conserved Domains (1) summary
      smart00224
      Location:971
      GGL; G protein gamma subunit-like motifs
    2. NM_031754.1NP_113942.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

      See identical proteins and their annotated locations for NP_113942.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6KKL4
      Conserved Domains (1) summary
      smart00224
      Location:971
      GGL; G protein gamma subunit-like motifs

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      4365222..4466060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093680.2XP_038949608.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1

      UniProtKB/TrEMBL
      A6KKL4
      Related
      ENSRNOP00000106054.1, ENSRNOT00000071133.4
      Conserved Domains (1) summary
      smart00224
      Location:971
      GGL; G protein gamma subunit-like motifs
    2. XM_039093681.2XP_038949609.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1

      UniProtKB/TrEMBL
      A6KKL4
      Conserved Domains (1) summary
      smart00224
      Location:971
      GGL; G protein gamma subunit-like motifs
    3. XM_039093682.2XP_038949610.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1

      UniProtKB/TrEMBL
      A6KKL4
      Conserved Domains (1) summary
      smart00224
      Location:971
      GGL; G protein gamma subunit-like motifs
    4. XM_063274690.1XP_063130760.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1

      UniProtKB/TrEMBL
      A6KKL4