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    Syt1 synaptotagmin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25716, updated on 27-Nov-2024

    Summary

    Official Symbol
    Syt1provided by RGD
    Official Full Name
    synaptotagmin 1provided by RGD
    Primary source
    RGD:3803
    See related
    EnsemblRapid:ENSRNOG00000006426 AllianceGenome:RGD:3803
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    P65
    Summary
    Enables several functions, including calcium ion sensor activity; phospholipid binding activity; and syntaxin binding activity. Involved in several processes, including detection of calcium ion; positive regulation of dopamine secretion; and regulation of vesicle-mediated transport. Located in several cellular components, including excitatory synapse; neuron projection terminus; and secretory vesicle. Is active in several cellular components, including hippocampal mossy fiber to CA3 synapse; postsynaptic cytosol; and presynaptic cytosol. Biomarker of visual epilepsy. Orthologous to human SYT1 (synaptotagmin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 991.0) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Syt1 in Genome Data Viewer
    Location:
    7q21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (45699649..46244460, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (43813204..44358020, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (50084063..50638996, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene ribosomal protein L26, pseudogene 10 Neighboring gene pro-apoptotic WT1 regulator Neighboring gene uncharacterized LOC120093582 Neighboring gene uncharacterized LOC120093799 Neighboring gene uncharacterized LOC102547595 Neighboring gene uncharacterized LOC134479870 Neighboring gene high mobility group protein B1-like Neighboring gene BRCA1/BRCA2-containing complex, subunit 3, domain containing Neighboring gene ribosomal protein L31, pseudogene 2 Neighboring gene uncharacterized LOC120093800 Neighboring gene Histone deacetylase 1, pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SNARE binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables SNARE binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables calcium ion sensor activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables calcium ion sensor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion sensor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-dependent phospholipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium-dependent phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables clathrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding EXP
    Inferred from Experiment
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular condensate scaffold activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables molecular condensate scaffold activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylserine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables syntaxin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables syntaxin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables syntaxin-1 binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables syntaxin-1 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables syntaxin-1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables syntaxin-3 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion-regulated exocytosis of neurotransmitter ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium-dependent activation of synaptic vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in calcium-dependent activation of synaptic vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium-ion regulated exocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to calcium ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in detection of calcium ion IC
    Inferred by Curator
    more info
    PubMed 
    involved_in detection of calcium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in fast, calcium ion-dependent exocytosis of neurotransmitter ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fast, calcium ion-dependent exocytosis of neurotransmitter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in membraneless organelle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium ion-dependent exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of calcium ion-dependent exocytosis of neurotransmitter ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium ion-dependent exocytosis of neurotransmitter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dopamine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic transmission ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of vesicle fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein heterooligomerization IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in regulation of calcium ion-dependent exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of calcium ion-dependent exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of calcium ion-dependent exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of dopamine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of regulated secretory pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synaptic transmission, glutamatergic ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of synaptic vesicle exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of synaptic vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of vesicle fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to calcium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within spontaneous neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic vesicle exocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within synchronous neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle docking IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vesicle docking IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vesicle fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromaffin granule membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dense core granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dense core granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dense core granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in excitatory synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in hippocampal mossy fiber to CA3 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in terminal bouton HDA PubMed 

    General protein information

    Preferred Names
    synaptotagmin-1
    Names
    synaptotagmin I
    sytI

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033680.2NP_001028852.2  synaptotagmin-1

      See identical proteins and their annotated locations for NP_001028852.2

      Status: VALIDATED

      Source sequence(s)
      AA924659, AJ617621, CB615786, CB731032, CO398869
      UniProtKB/Swiss-Prot
      P21707, Q3S2E6, Q707P5
      UniProtKB/TrEMBL
      A6IGE2
      Related
      ENSRNOP00000049624.2, ENSRNOT00000048880.4
      Conserved Domains (3) summary
      cd08385
      Location:142264
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08402
      Location:273408
      C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
      cd21963
      Location:5112
      Syt1_N; N-terminal domain of synaptotagmin-1 (Syt1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      45699649..46244460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008765353.4XP_008763575.2  synaptotagmin-1 isoform X2

      UniProtKB/TrEMBL
      A6IGE2
      Conserved Domains (3) summary
      cd08385
      Location:139261
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08402
      Location:270405
      C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
      cd21963
      Location:5112
      Syt1_N; N-terminal domain of synaptotagmin-1 (Syt1) and similar proteins
    2. XM_063263065.1XP_063119135.1  synaptotagmin-1 isoform X3

    3. XM_017594679.3XP_017450168.1  synaptotagmin-1 isoform X1

      UniProtKB/Swiss-Prot
      P21707, Q3S2E6, Q707P5
      UniProtKB/TrEMBL
      A6IGE2
      Conserved Domains (3) summary
      cd08385
      Location:142264
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08402
      Location:273408
      C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
      cd21963
      Location:5112
      Syt1_N; N-terminal domain of synaptotagmin-1 (Syt1) and similar proteins
    4. XM_063263063.1XP_063119133.1  synaptotagmin-1 isoform X2

    5. XM_063263062.1XP_063119132.1  synaptotagmin-1 isoform X2

    6. XM_039078497.2XP_038934425.1  synaptotagmin-1 isoform X1

      UniProtKB/Swiss-Prot
      P21707, Q3S2E6, Q707P5
      UniProtKB/TrEMBL
      A6IGE2
      Conserved Domains (3) summary
      cd08385
      Location:142264
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08402
      Location:273408
      C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
      cd21963
      Location:5112
      Syt1_N; N-terminal domain of synaptotagmin-1 (Syt1) and similar proteins
    7. XM_063263064.1XP_063119134.1  synaptotagmin-1 isoform X2