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    Uts2 urotensin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29180, updated on 27-Nov-2024

    Summary

    Official Symbol
    Uts2provided by RGD
    Official Full Name
    urotensin 2provided by RGD
    Primary source
    RGD:3930
    See related
    EnsemblRapid:ENSRNOG00000018393 AllianceGenome:RGD:3930
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    UII; U-II; Ucn2
    Summary
    Predicted to enable hormone activity. Involved in several processes, including regulation of blood pressure; regulation of circadian sleep/wake cycle; and regulation of heart rate. Located in extracellular space. Used to study hypertension. Biomarker of asthma; cardiomyopathy; endomyocardial fibrosis; myocardial infarction; and pulmonary hypertension. Human ortholog(s) of this gene implicated in gestational diabetes and type 2 diabetes mellitus. Orthologous to human UTS2 (urotensin 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 4.7), Testes (RPKM 1.8) and 2 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Uts2 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (166725471..166739063)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (161450846..161456235)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (168078748..168084133)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC102556501 Neighboring gene period circadian regulator 3 Neighboring gene uncharacterized LOC134487044 Neighboring gene vesicle-associated membrane protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in blood vessel diameter maintenance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of blood pressure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of glomerular filtration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of heart rate IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of urine volume IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of blood pressure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of circadian sleep/wake cycle, REM sleep IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of circadian sleep/wake cycle, wakefulness IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of collagen biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of fibroblast migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of fibroblast proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of heart rate IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of synaptic transmission, cholinergic IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to testosterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    urotensin-2
    Names
    urocortin 2
    urotensin II

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429544.1NP_001416473.1  urotensin-2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q9QZQ4
      UniProtKB/TrEMBL
      A6IUE7
    2. NM_019160.3NP_062033.1  urotensin-2 precursor

      See identical proteins and their annotated locations for NP_062033.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q9QZQ4
      UniProtKB/TrEMBL
      A6IUE7
      Related
      ENSRNOP00000024798.3, ENSRNOT00000024798.6
      Conserved Domains (1) summary
      pfam02083
      Location:112123
      Urotensin_II; Urotensin II

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      166725471..166739063
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287245.1XP_063143315.1  urotensin-2 isoform X1