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    Tjap1 tight junction associated protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316233, updated on 3-Dec-2024

    Summary

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    Official Symbol
    Tjap1provided by RGD
    Official Full Name
    tight junction associated protein 1provided by RGD
    Primary source
    RGD:1308708
    See related
    EnsemblRapid:ENSRNOG00000018980 AllianceGenome:RGD:1308708
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tjp4
    Summary
    Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus; endosome; and plasma membrane. Predicted to be active in trans-Golgi network. Orthologous to human TJAP1 (tight junction associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 88.3), Adrenal (RPKM 52.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tjap1 in Genome Data Viewer
    Location:
    9q12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (22198984..22223201)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (14701418..14725623)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (17086452..17110770)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily C member 10 Neighboring gene delta like non-canonical Notch ligand 2 Neighboring gene U6 spliceosomal RNA Neighboring gene leucine rich repeat containing 73 Neighboring gene Yip1 domain family, member 3 Neighboring gene RNA polymerase I and III subunit C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Pilt is a coiled-coil domain-containing protein that localizes at the trans-Golgi complex and regulates its structure. Tamaki H, et al. FEBS Lett, 2012 Sep 21. PMID 22841714
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tight junction-associated protein 1
    Names
    tight junction protein 4 (peripheral)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108203.2 → NP_001101673.1  tight junction-associated protein 1

      See identical proteins and their annotated locations for NP_001101673.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2K0W5, A6JIR8, D3ZU31
      Conserved Domains (2) summary
      COG1196
      Location:17 → 161
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:275 → 542
      Pilt; Protein incorporated later into Tight Junctions

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      22198984..22223201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244529.5 → XP_006244591.1  tight junction-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006244591.1

      UniProtKB/TrEMBL
      A0A0G2K0W5, A0A8I6GDP5
      Conserved Domains (2) summary
      COG1196
      Location:17 → 171
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:285 → 552
      Pilt; Protein incorporated later into Tight Junctions

    2. XM_063267096.1 → XP_063123166.1  tight junction-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0W5, A0A8I6GDP5

    3. XM_063267110.1 → XP_063123180.1  tight junction-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K0W5, A6JIR8, D3ZU31

    4. XM_063267097.1 → XP_063123167.1  tight junction-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0W5, A0A8I6GDP5
      Related
      ENSRNOP00000086121.1, ENSRNOT00000115530.2

    5. XM_017596429.3 → XP_017451918.1  tight junction-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K0W5, A6JIR8, D3ZU31
      Conserved Domains (2) summary
      COG1196
      Location:17 → 161
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:275 → 542
      Pilt; Protein incorporated later into Tight Junctions

    6. XM_063267102.1 → XP_063123172.1  tight junction-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K0W5, A6JIR8, D3ZU31

    7. XM_063267103.1 → XP_063123173.1  tight junction-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K0W5, A6JIR8, D3ZU31

    8. XM_063267104.1 → XP_063123174.1  tight junction-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K0W5, A6JIR8, D3ZU31

    9. XM_039083524.2 → XP_038939452.1  tight junction-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0W5, A0A8I6GDP5
      Conserved Domains (2) summary
      COG1196
      Location:17 → 171
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:285 → 552
      Pilt; Protein incorporated later into Tight Junctions

    10. XM_063267100.1 → XP_063123170.1  tight junction-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0W5, A0A8I6GDP5

    11. XM_039083522.2 → XP_038939450.1  tight junction-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0W5, A0A8I6GDP5
      Conserved Domains (2) summary
      COG1196
      Location:17 → 171
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:285 → 552
      Pilt; Protein incorporated later into Tight Junctions

    12. XM_063267099.1 → XP_063123169.1  tight junction-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0W5, A0A8I6GDP5

    13. XM_063267107.1 → XP_063123177.1  tight junction-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K0W5, A6JIR8, D3ZU31

    14. XM_063267108.1 → XP_063123178.1  tight junction-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K0W5, A6JIR8, D3ZU31

    15. XM_017596425.3 → XP_017451914.1  tight junction-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0W5, A0A8I6GDP5
      Conserved Domains (2) summary
      COG1196
      Location:17 → 171
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:285 → 552
      Pilt; Protein incorporated later into Tight Junctions

    16. XM_063267106.1 → XP_063123176.1  tight junction-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K0W5, A6JIR8, D3ZU31
      Related
      ENSRNOP00000025660.3, ENSRNOT00000025660.7

    17. XM_063267105.1 → XP_063123175.1  tight junction-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K0W5, A6JIR8, D3ZU31

    18. XM_063267109.1 → XP_063123179.1  tight junction-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K0W5, A6JIR8, D3ZU31

    19. XM_063267112.1 → XP_063123182.1  tight junction-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K0W5, A6JIR8, D3ZU31

    20. XM_039083529.2 → XP_038939457.1  tight junction-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0W5, A0A8I6GDP5
      Conserved Domains (2) summary
      COG1196
      Location:17 → 171
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:285 → 552
      Pilt; Protein incorporated later into Tight Junctions

    21. XM_063267111.1 → XP_063123181.1  tight junction-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K0W5, A6JIR8, D3ZU31

    22. XM_063267098.1 → XP_063123168.1  tight junction-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0W5, A0A8I6GDP5

    23. XM_039083523.2 → XP_038939451.1  tight junction-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0W5, A0A8I6GDP5
      Conserved Domains (2) summary
      COG1196
      Location:17 → 171
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:285 → 552
      Pilt; Protein incorporated later into Tight Junctions

    24. XM_017596424.3 → XP_017451913.1  tight junction-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0W5, A0A8I6GDP5
      Conserved Domains (2) summary
      COG1196
      Location:17 → 171
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:285 → 552
      Pilt; Protein incorporated later into Tight Junctions

    25. XM_039083525.2 → XP_038939453.1  tight junction-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0W5, A0A8I6GDP5
      Conserved Domains (2) summary
      COG1196
      Location:17 → 171
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:285 → 552
      Pilt; Protein incorporated later into Tight Junctions

    26. XM_039083530.2 → XP_038939458.1  tight junction-associated protein 1 isoform X3

      Conserved Domains (1) summary
      pfam15453
      Location:151 → 418
      Pilt; Protein incorporated later into Tight Junctions
    Nucleotide Protein Strain
    Heading Accession and Version

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