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    Slc7a8 solute carrier family 7 member 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84551, updated on 27-Nov-2024

    Summary

    Official Symbol
    Slc7a8provided by RGD
    Official Full Name
    solute carrier family 7 member 8provided by RGD
    Primary source
    RGD:619904
    See related
    EnsemblRapid:ENSRNOG00000014311 AllianceGenome:RGD:619904
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lat2; Lat4
    Summary
    Predicted to enable several functions, including neutral L-amino acid transmembrane transporter activity; peptide antigen binding activity; and secondary active transmembrane transporter activity. Predicted to be involved in carboxylic acid transport and thyroid hormone transport. Predicted to act upstream of or within L-amino acid transport. Predicted to be located in apical plasma membrane; basolateral plasma membrane; and microvillus membrane. Orthologous to human SLC7A8 (solute carrier family 7 member 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 179.0), Adrenal (RPKM 148.6) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Slc7a8 in Genome Data Viewer
    Location:
    15p13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (32153016..32212715, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (28183013..28242717, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (33369245..33428942, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 14 open reading frame 119 Neighboring gene ciliated left-right organizer metallopeptidase Neighboring gene uncharacterized LOC120096982 Neighboring gene CCAAT/enhancer binding protein epsilon Neighboring gene uncharacterized LOC134482118 Neighboring gene ring finger protein 212B Neighboring gene CEBPZ opposite strand, pseudogene 2 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-alanine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables L-amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-leucine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glycine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables neutral L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables neutral L-amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables organic cation transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide antigen binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables thyroid hormone transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables thyroid hormone transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables toxin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in L-alanine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within L-amino acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-leucine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-leucine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amino acid import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in amino acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neutral amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neutral amino acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neutral amino acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proline transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in thyroid hormone transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in thyroid hormone transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in tryptophan transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in valine transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microvillus membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    large neutral amino acids transporter small subunit 2
    Names
    L-type amino acid transporter 2
    cationic amino acid transporter y+ system
    solute carrier family 7 (amino acid transporter light chain, L system), member 8
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053442.1NP_445894.1  large neutral amino acids transporter small subunit 2

      See identical proteins and their annotated locations for NP_445894.1

      Status: PROVISIONAL

      Source sequence(s)
      AB024400
      UniProtKB/Swiss-Prot
      Q9WVR6
      UniProtKB/TrEMBL
      A6KGW0, A6KGW1
      Related
      ENSRNOP00000019618.3, ENSRNOT00000019618.6
      Conserved Domains (1) summary
      TIGR00911
      Location:1499
      2A0308; L-type amino acid transporter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      32153016..32212715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)