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    Acaca acetyl-CoA carboxylase alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60581, updated on 3-Dec-2024

    Summary

    Official Symbol
    Acacaprovided by RGD
    Official Full Name
    acetyl-CoA carboxylase alphaprovided by RGD
    Primary source
    RGD:621248
    See related
    EnsemblRapid:ENSRNOG00000034013 AllianceGenome:RGD:621248
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ACC1; Acac
    Summary
    Enables acetyl-CoA carboxylase activity and biotin binding activity. Involved in several processes, including fatty acid biosynthetic process; response to nutrient; and response to xenobiotic stimulus. Predicted to be located in actin cytoskeleton; cytosol; and fibrillar center. Predicted to be active in mitochondrion. Used to study steatotic liver disease. Biomarker of metabolic dysfunction-associated steatohepatitis and metabolic dysfunction-associated steatotic liver disease. Orthologous to human ACACA (acetyl-CoA carboxylase alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 596.3), Thymus (RPKM 517.4) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Acaca in Genome Data Viewer
    Location:
    10q26
    Exon count:
    59
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (69511627..69773888)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (69014261..69276453)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (71519392..71719910)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S15a, pseudogene 2 Neighboring gene dual specificity phosphatase 14 Neighboring gene transcriptional adaptor 2A Neighboring gene similar to human chromosome 17 open reading frame 78 Neighboring gene ribosomal protein L17, pseudogene 8 Neighboring gene uncharacterized LOC134480840 Neighboring gene apoptosis antagonizing transcription factor Neighboring gene LIM homeobox 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables acetyl-CoA carboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables acetyl-CoA carboxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acetyl-CoA carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables acetyl-CoA carboxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables biotin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in acetyl-CoA metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in acetyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to prostaglandin E stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to prostaglandin E stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in malonyl-CoA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to nutrient IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to organic cyclic compound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in tissue homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within tissue homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    acetyl-CoA carboxylase 1
    Names
    ACC-alpha
    acetyl-coenzyme A carboxylase alpha
    NP_071529.2
    XP_038942680.1
    XP_038942681.1
    XP_038942682.1
    XP_038942683.1
    XP_038942685.1
    XP_038942686.1
    XP_063125854.1
    XP_063125855.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022193.2NP_071529.2  acetyl-CoA carboxylase 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      A1EC79, P11497, P97902
      UniProtKB/TrEMBL
      D3ZRA3
      Related
      ENSRNOP00000094595.1, ENSRNOT00000115196.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      69511627..69773888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086752.2XP_038942680.1  acetyl-CoA carboxylase 1 isoform X1

      UniProtKB/Swiss-Prot
      A1EC79, P11497, P97902
      UniProtKB/TrEMBL
      A0A8I6A239
      Related
      ENSRNOP00000086394.1, ENSRNOT00000116202.2
      Conserved Domains (5) summary
      COG0439
      Location:156658
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:709856
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00364
      Location:791856
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:17072255
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:8581607
      ACC_central; Acetyl-CoA carboxylase, central region
    2. XM_039086753.2XP_038942681.1  acetyl-CoA carboxylase 1 isoform X2

      UniProtKB/Swiss-Prot
      A1EC79, P11497, P97902
      Conserved Domains (5) summary
      COG0439
      Location:156658
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:709856
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00364
      Location:791856
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:16992247
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:8581599
      ACC_central; Acetyl-CoA carboxylase, central region
    3. XM_039086758.2XP_038942686.1  acetyl-CoA carboxylase 1 isoform X3

      UniProtKB/Swiss-Prot
      A1EC79, P11497, P97902
      UniProtKB/TrEMBL
      D3ZRA3
      Conserved Domains (5) summary
      COG0439
      Location:117619
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:670817
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00364
      Location:752817
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:16682216
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:8191568
      ACC_central; Acetyl-CoA carboxylase, central region
    4. XM_063269785.1XP_063125855.1  acetyl-CoA carboxylase 1 isoform X4

      UniProtKB/Swiss-Prot
      A1EC79, P11497, P97902
      UniProtKB/TrEMBL
      A0A8I5ZM24
    5. XM_039086755.2XP_038942683.1  acetyl-CoA carboxylase 1 isoform X3

      UniProtKB/Swiss-Prot
      A1EC79, P11497, P97902
      UniProtKB/TrEMBL
      D3ZRA3
      Conserved Domains (5) summary
      COG0439
      Location:117619
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:670817
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00364
      Location:752817
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:16682216
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:8191568
      ACC_central; Acetyl-CoA carboxylase, central region
    6. XM_039086754.2XP_038942682.1  acetyl-CoA carboxylase 1 isoform X3

      UniProtKB/Swiss-Prot
      A1EC79, P11497, P97902
      UniProtKB/TrEMBL
      D3ZRA3
      Conserved Domains (5) summary
      COG0439
      Location:117619
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:670817
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00364
      Location:752817
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:16682216
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:8191568
      ACC_central; Acetyl-CoA carboxylase, central region
    7. XM_039086757.2XP_038942685.1  acetyl-CoA carboxylase 1 isoform X3

      UniProtKB/Swiss-Prot
      A1EC79, P11497, P97902
      UniProtKB/TrEMBL
      D3ZRA3
      Conserved Domains (5) summary
      COG0439
      Location:117619
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:670817
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00364
      Location:752817
      Biotin_lipoyl; Biotin-requiring enzyme
      pfam01039
      Location:16682216
      Carboxyl_trans; Carboxyl transferase domain
      pfam08326
      Location:8191568
      ACC_central; Acetyl-CoA carboxylase, central region
    8. XM_063269784.1XP_063125854.1  acetyl-CoA carboxylase 1 isoform X3

      UniProtKB/Swiss-Prot
      A1EC79, P11497, P97902
      UniProtKB/TrEMBL
      D3ZRA3