U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ptk7 protein tyrosine kinase 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301242, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ptk7provided by RGD
    Official Full Name
    protein tyrosine kinase 7provided by RGD
    Primary source
    RGD:1310472
    See related
    EnsemblRapid:ENSRNOG00000039976 AllianceGenome:RGD:1310472
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein tyrosine kinase activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; cellular response to retinoic acid; and positive regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within several processes, including cochlea morphogenesis; heart development; and morphogenesis of an epithelium. Predicted to be located in cell-cell junction and membrane. Predicted to be active in plasma membrane. Orthologous to human PTK7 (protein tyrosine kinase 7 (inactive)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 114.4), Uterus (RPKM 97.1) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ptk7 in Genome Data Viewer
    Location:
    9q12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (21849756..21916077)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (14352155..14418473)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (16662588..16729888)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L2 Neighboring gene kinesin light chain 4 Neighboring gene uncharacterized LOC120094784 Neighboring gene serum response factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT enables transmembrane receptor protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within axis elongation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cochlea morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within convergent extension ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within coronary vasculature development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within establishment of epithelial cell apical/basal polarity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within establishment of planar polarity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lung-associated mesenchyme development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neural tube closure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    NOT acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ventricular septum development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    inactive tyrosine-protein kinase 7
    Names
    PTK7 protein tyrosine kinase 7
    tyrosine-protein kinase-like 7
    NP_001382670.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395741.1NP_001382670.1  inactive tyrosine-protein kinase 7 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6AKN3, A0A8I6ALM9
      Related
      ENSRNOP00000094298.1, ENSRNOT00000108486.2
      Conserved Domains (5) summary
      cd05046
      Location:7821055
      PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4
      pfam13927
      Location:585660
      Ig_3; Immunoglobulin domain
      cd00096
      Location:592595
      Ig; Ig strand A' [structural motif]
      cd05760
      Location:120214
      Ig2_PTK7; Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7
      cl11960
      Location:404490
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      21849756..21916077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106889.2: Suppressed sequence

      Description
      NM_001106889.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.