U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ppp1r12a protein phosphatase 1, regulatory subunit 12A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116670, updated on 3-Dec-2024

    Summary

    Official Symbol
    Ppp1r12aprovided by RGD
    Official Full Name
    protein phosphatase 1, regulatory subunit 12Aprovided by RGD
    Primary source
    RGD:620013
    See related
    EnsemblRapid:ENSRNOG00000004925 AllianceGenome:RGD:620013
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    M110; MBSP; Mypt1
    Summary
    Enables phosphoprotein phosphatase activity. Predicted to be involved in several processes, including centrosome cycle; positive regulation of transcription by RNA polymerase II; and protein dephosphorylation. Predicted to act upstream of or within cellular response to xenobiotic stimulus and regulation of nucleocytoplasmic transport. Predicted to be located in several cellular components, including contractile muscle fiber; cytoskeleton; and kinetochore. Predicted to be part of PTW/PP1 phosphatase complex. Predicted to be active in A band and Z disc. Orthologous to human PPP1R12A (protein phosphatase 1 regulatory subunit 12A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Uterus (RPKM 270.9), Heart (RPKM 247.7) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ppp1r12a in Genome Data Viewer
    Location:
    7q21
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (45368922..45480158)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (43482808..43593689)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (51404971..51515382, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093580 Neighboring gene protein tyrosine phosphatase, receptor type, Q Neighboring gene otogelin-like Neighboring gene small nucleolar RNA SNORA48 Neighboring gene ribosomal protein L26, pseudogene 10 Neighboring gene uncharacterized LOC120093582 Neighboring gene pro-apoptotic WT1 regulator

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 14-3-3 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables 14-3-3 protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables enzyme inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables enzyme inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables myosin phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatase regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in centrosome cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in centrosome cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of catalytic activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT involved_in regulation of establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of nucleocytoplasmic transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of nucleocytoplasmic transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in A band IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in A band IEA
    Inferred from Electronic Annotation
    more info
     
    located_in A band ISO
    Inferred from Sequence Orthology
    more info
     
    located_in A band ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of PTW/PP1 phosphatase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of PTW/PP1 phosphatase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of PTW/PP1 phosphatase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Z disc ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in contractile muscle fiber ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein phosphatase 1 regulatory subunit 12A
    Names
    PP-1M
    myosin phosphatase, target subunit 1
    myosin phosphatase-targeting subunit 1
    protein phosphatase 1, regulatory (inhibitor) subunit 12A
    protein phosphatase myosin-binding subunit
    protein phosphatase subunit 1M
    serine/threonine protein phosphatase PP1 smooth muscle regulatory subunit M110
    smooth muscle myosin phosphatase myosin-binding subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053890.2NP_446342.2  protein phosphatase 1 regulatory subunit 12A

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q10728, Q62937, Q9WU33
      UniProtKB/TrEMBL
      A6IGD8
      Related
      ENSRNOP00000104388.1, ENSRNOT00000152362.1
      Conserved Domains (4) summary
      PHA03095
      Location:43272
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
      pfam15898
      Location:877975
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cd21944
      Location:603659
      IPD_MYPT1; inhibitory phosphorylation domain of myosin phosphatase targeting subunit 1(MYPT1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      45368922..45480158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241311.3XP_006241373.1  protein phosphatase 1 regulatory subunit 12A isoform X3

      See identical proteins and their annotated locations for XP_006241373.1

      UniProtKB/TrEMBL
      A0A0G2JWJ0, A0A8I6ATJ5, A6IGD6
      Related
      ENSRNOP00000069900.1, ENSRNOT00000080285.3
      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:9331031
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    2. XM_006241315.3XP_006241377.1  protein phosphatase 1 regulatory subunit 12A isoform X8

      See identical proteins and their annotated locations for XP_006241377.1

      UniProtKB/TrEMBL
      A6IGD7, D4ACS0
      Related
      ENSRNOP00000040934.7, ENSRNOT00000050037.8
      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:873971
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    3. XM_063262871.1XP_063118941.1  protein phosphatase 1 regulatory subunit 12A isoform X6

      UniProtKB/Swiss-Prot
      Q10728, Q62937, Q9WU33
    4. XM_063262872.1XP_063118942.1  protein phosphatase 1 regulatory subunit 12A isoform X10

      UniProtKB/TrEMBL
      D4ACS0
    5. XM_063262873.1XP_063118943.1  protein phosphatase 1 regulatory subunit 12A isoform X11

      UniProtKB/TrEMBL
      D4A1S6, D4ACS0
      Related
      ENSRNOP00000045260.6, ENSRNOT00000041473.7
    6. XM_006241308.3XP_006241370.1  protein phosphatase 1 regulatory subunit 12A isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y8E5, A0A8I6ATJ5
      Related
      ENSRNOP00000078058.1, ENSRNOT00000108069.2
      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:9711069
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    7. XM_006241313.3XP_006241375.1  protein phosphatase 1 regulatory subunit 12A isoform X5

      UniProtKB/TrEMBL
      D4ACS0
      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:9111009
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    8. XM_039078253.2XP_038934181.1  protein phosphatase 1 regulatory subunit 12A isoform X2

      UniProtKB/Swiss-Prot
      Q10728, Q62937, Q9WU33
      Conserved Domains (4) summary
      PHA03095
      Location:43272
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
      pfam15898
      Location:9341032
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cd21944
      Location:660716
      IPD_MYPT1; inhibitory phosphorylation domain of myosin phosphatase targeting subunit 1(MYPT1)
    9. XM_039078254.2XP_038934182.1  protein phosphatase 1 regulatory subunit 12A isoform X7

      UniProtKB/TrEMBL
      D4ACS0
      Conserved Domains (4) summary
      PHA03095
      Location:43272
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
      pfam15898
      Location:874972
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cl40436
      Location:609655
      IPD_PPP1R12; inhibitory phosphorylation domain of protein phosphatase 1 regulatory subunit 12 (PPP1R12) family
    10. XM_006241312.3XP_006241374.1  protein phosphatase 1 regulatory subunit 12A isoform X4

      UniProtKB/Swiss-Prot
      Q10728, Q62937, Q9WU33
      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:9151013
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    11. XM_039078255.2XP_038934183.1  protein phosphatase 1 regulatory subunit 12A isoform X9

      UniProtKB/TrEMBL
      D4ACS0
      Conserved Domains (4) summary
      PHA03095
      Location:43272
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
      pfam15898
      Location:855953
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cd21944
      Location:589637
      IPD_MYPT1; inhibitory phosphorylation domain of myosin phosphatase targeting subunit 1(MYPT1)
    12. XM_006241316.5XP_006241378.1  protein phosphatase 1 regulatory subunit 12A isoform X12

      UniProtKB/TrEMBL
      A0A8I6ATJ5
      Conserved Domains (4) summary
      cd00204
      Location:9104
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam13637
      Location:2376
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:795893
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:2253
      ANK; ANK repeat [structural motif]