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    F8 coagulation factor VIII [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302470, updated on 27-Nov-2024

    Summary

    Official Symbol
    F8provided by RGD
    Official Full Name
    coagulation factor VIIIprovided by RGD
    Primary source
    RGD:727845
    See related
    EnsemblRapid:ENSRNOG00000031197 AllianceGenome:RGD:727845
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable copper ion binding activity and oxidoreductase activity. Involved in blood coagulation, intrinsic pathway. Located in extracellular space. Used to study factor VIII deficiency; hemarthrosis; and hyperhomocysteinemia. Human ortholog(s) of this gene implicated in factor VIII deficiency. Orthologous to human F8 (coagulation factor VIII). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 92.8), Heart (RPKM 64.9) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    18p13
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (155237..187186)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (140848..172330)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (367862..399242, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene BRCA1/BRCA2-containing complex, subunit 3, pseudogene 7 Neighboring gene FUN14 domain containing 2 Neighboring gene uncharacterized LOC134482991 Neighboring gene mature T-cell proliferation 1 Neighboring gene C-X9-C motif containing 4 Neighboring gene uncharacterized LOC134482992 Neighboring gene myotubularin related protein 1 Neighboring gene zinc finger protein 91, pseudogene 2 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in blood coagulation, intrinsic pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in blood coagulation, intrinsic pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    coagulation factor VIII
    Names
    coagulation factor VIII, procoagulant component

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183331.2NP_899160.2  coagulation factor VIII precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      D3ZEB1, Q7TN96
      Related
      ENSRNOP00000050792.5, ENSRNOT00000045926.6
      Conserved Domains (2) summary
      cd00057
      Location:21032251
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl19115
      Location:387563
      Cupredoxin; Cupredoxin superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      155237..187186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277282.1XP_063133352.1  coagulation factor VIII isoform X1

    2. XM_063277283.1XP_063133353.1  coagulation factor VIII isoform X2

    3. XM_039096756.2XP_038952684.1  coagulation factor VIII isoform X3

      UniProtKB/TrEMBL
      Q7TN96
      Conserved Domains (1) summary
      cl19115
      Location:387563
      Cupredoxin; Cupredoxin superfamily
    4. XM_039096757.2XP_038952685.1  coagulation factor VIII isoform X4

      Conserved Domains (1) summary
      cl19115
      Location:387563
      Cupredoxin; Cupredoxin superfamily
    5. XM_063277284.1XP_063133354.1  coagulation factor VIII isoform X5

    6. XM_063277285.1XP_063133355.1  coagulation factor VIII isoform X6