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    Kcnmb4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 66016, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kcnmb4provided by RGD
    Official Full Name
    potassium calcium-activated channel subfamily M regulatory beta subunit 4provided by RGD
    Primary source
    RGD:620728
    See related
    EnsemblRapid:ENSRNOG00000054458 AllianceGenome:RGD:620728
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Predicted to be involved in detection of calcium ion; neuronal action potential; and potassium ion transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Orthologous to human KCNMB4 (potassium calcium-activated channel subfamily M regulatory beta subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 95.9), Thymus (RPKM 24.1) and 4 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Kcnmb4 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (53952150..54005101, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (52066145..52119098, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (59461808..59514759, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, receptor type, R Neighboring gene uncharacterized LOC120093595 Neighboring gene protein tyrosine phosphatase, receptor type, B Neighboring gene CCR4-NOT transcription complex, subunit 2 Neighboring gene protein disulfide isomerase family A, member 4, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in action potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in detection of calcium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in detection of calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in detection of calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuronal action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuronal action potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of presynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of voltage-gated potassium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    calcium-activated potassium channel subunit beta-4
    Names
    BK channel subunit beta-4
    BKbeta4
    calcium activated potassium channel beta 4 subunit
    calcium-activated potassium channel, subfamily M subunit beta-4
    charybdotoxin receptor subunit beta-4
    k(VCA)beta-4
    maxi K channel subunit beta-4
    potassium channel subfamily M regulatory beta subunit 4
    potassium large conductance calcium-activated channel, subfamily M, beta member 4
    slo-beta-4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023960.2NP_076450.1  calcium-activated potassium channel subunit beta-4

      See identical proteins and their annotated locations for NP_076450.1

      Status: PROVISIONAL

      Source sequence(s)
      AY028605
      UniProtKB/Swiss-Prot
      Q9ESK8
      UniProtKB/TrEMBL
      B1WBP1
      Related
      ENSRNOP00000075448.1, ENSRNOT00000085579.3
      Conserved Domains (1) summary
      pfam03185
      Location:8203
      CaKB; Calcium-activated potassium channel, beta subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      53952150..54005101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)