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    Guca1b guanylate cyclase activator 1B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316218, updated on 27-Nov-2024

    Summary

    Official Symbol
    Guca1bprovided by RGD
    Official Full Name
    guanylate cyclase activator 1Bprovided by RGD
    Primary source
    RGD:1308191
    See related
    EnsemblRapid:ENSRNOG00000015623 AllianceGenome:RGD:1308191
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity and calcium sensitive guanylate cyclase activator activity. Predicted to be involved in regulation of signal transduction and visual perception. Predicted to act upstream of or within phototransduction and regulation of guanylate cyclase activity. Located in photoreceptor inner segment and photoreceptor outer segment. Human ortholog(s) of this gene implicated in retinitis pigmentosa 48. Orthologous to human GUCA1B (guanylate cyclase activator 1B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 2.3), Adrenal (RPKM 2.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Guca1b in Genome Data Viewer
    Location:
    9q12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (21097274..21105107, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (13599619..13607455, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (15621083..15629017, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480553 Neighboring gene ciliary microtubule inner protein 3 Neighboring gene U6 spliceosomal RNA Neighboring gene guanylate cyclase activator 1A Neighboring gene mitochondrial ribosomal protein S10 Neighboring gene transcriptional regulating factor 1 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium sensitive guanylate cyclase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium sensitive guanylate cyclase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanylate cyclase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    acts_upstream_of_or_within phototransduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of guanylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in visual perception IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within visual perception ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cone photoreceptor outer segment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cone photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in photoreceptor inner segment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in photoreceptor inner segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in photoreceptor inner segment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in photoreceptor outer segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    guanylyl cyclase-activating protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108198.1NP_001101668.1  guanylyl cyclase-activating protein 2

      See identical proteins and their annotated locations for NP_001101668.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473987
      UniProtKB/TrEMBL
      A6JIK6, D3ZID7
      Related
      ENSRNOP00000020950.3, ENSRNOT00000020950.6
      Conserved Domains (1) summary
      COG5126
      Location:15175
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      21097274..21105107 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)