U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Prph2 peripherin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25534, updated on 27-Nov-2024

    Summary

    Official Symbol
    Prph2provided by RGD
    Official Full Name
    peripherin 2provided by RGD
    Primary source
    RGD:3549
    See related
    EnsemblRapid:ENSRNOG00000068377 AllianceGenome:RGD:3549
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rds; RSRDS
    Summary
    Predicted to enable protein homodimerization activity. Involved in response to low light intensity stimulus. Predicted to be located in photoreceptor outer segment. Predicted to be active in plasma membrane. Biomarker of retinal disease. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; eye degenerative disease (multiple); and fundus albipunctatus. Orthologous to human PRPH2 (peripherin 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 1.1) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Prph2 in Genome Data Viewer
    Location:
    9q12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (21563770..21579074, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (14066149..14081454, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (16085933..16386176, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene ubiquitin protein ligase E3 component n-recognin 2 Neighboring gene U6 spliceosomal RNA Neighboring gene BICRA like chromatin remodeling complex associated protein Neighboring gene tubulin folding cofactor C Neighboring gene uncharacterized LOC134480555

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in photoreceptor inner segment IEA
    Inferred from Electronic Annotation
    more info
     
    located_in photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    peripherin-2
    Names
    retinal degeneration slow protein
    retinal degeneration, slow

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013021.2NP_037153.1  peripherin-2

      See identical proteins and their annotated locations for NP_037153.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      P17438
      UniProtKB/TrEMBL
      A6JIL5
      Related
      ENSRNOP00000095739.1, ENSRNOT00000108165.2
      Conserved Domains (1) summary
      cd03162
      Location:120262
      peripherin_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      21563770..21579074 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)