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    Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361042, updated on 27-Nov-2024

    Summary

    Symbol
    Pck2provided by RGD
    Full Name
    phosphoenolpyruvate carboxykinase 2 (mitochondrial)provided by RGD
    Primary source
    RGD:1311112
    See related
    EnsemblRapid:ENSRNOG00000018536 AllianceGenome:RGD:1311112
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PEPCK-M
    Summary
    Enables phosphoenolpyruvate carboxykinase (GTP) activity. Involved in several processes, including carboxylic acid metabolic process; gluconeogenesis; and positive regulation of insulin secretion. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Orthologous to human PCK2 (phosphoenolpyruvate carboxykinase 2, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 137.9), Kidney (RPKM 104.9) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pck2 in Genome Data Viewer
    Location:
    15p13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (32997853..33006691)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (29027891..29036729)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34216735..34224357)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552093 Neighboring gene copine 6 Neighboring gene neural retina leucine zipper Neighboring gene uncharacterized LOC120096988 Neighboring gene DDB1 and CUL4 associated factor 11 Neighboring gene uncharacterized LOC102552219

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables manganese ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoenolpyruvate carboxykinase (GTP) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphoenolpyruvate carboxykinase (GTP) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphoenolpyruvate carboxykinase (GTP) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoenolpyruvate carboxykinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in NADH oxidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in NADH oxidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to dexamethasone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to glucose stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to glucose stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to insulin stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to tumor necrosis factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in gluconeogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycerol biosynthetic process from pyruvate IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in hepatocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in oxaloacetate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in oxaloacetate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in propionate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in pyruvate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to dexamethasone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phosphoenolpyruvate carboxykinase [GTP], mitochondrial
    NP_001101847.2
    XP_063130477.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108377.2NP_001101847.2  phosphoenolpyruvate carboxykinase [GTP], mitochondrial

      Status: VALIDATED

      Source sequence(s)
      BC166766, CB787746
      UniProtKB/TrEMBL
      B2RYG2
      Related
      ENSRNOP00000025260.7, ENSRNOT00000025260.9
      Conserved Domains (1) summary
      cd00819
      Location:44633
      PEPCK_GTP; Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      32997853..33006691
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274407.1XP_063130477.1  phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1