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    Nrgn neurogranin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64356, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nrgnprovided by RGD
    Official Full Name
    neurograninprovided by RGD
    Primary source
    RGD:61833
    See related
    EnsemblRapid:ENSRNOG00000010688 AllianceGenome:RGD:61833
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RC3; BICKS
    Summary
    Enables calmodulin binding activity; phosphatidic acid binding activity; and phosphatidylinositol-3,4,5-trisphosphate binding activity. Involved in associative learning; modulation of chemical synaptic transmission; and telencephalon development. Located in several cellular components, including dendritic spine head; neuronal cell body; and trans-Golgi network transport vesicle membrane. Is active in glutamatergic synapse and postsynaptic membrane. Biomarker of hypothyroidism and visual epilepsy. Orthologous to human NRGN (neurogranin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 451.7), Lung (RPKM 23.7) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Nrgn in Genome Data Viewer
    Location:
    8q22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (45444223..45452417, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (37255462..37263659, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (40015049..40023193, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene endothelial cell adhesion molecule Neighboring gene V-set and immunoglobulin domain containing 2 Neighboring gene uncharacterized LOC103693043 Neighboring gene uncharacterized LOC108351844

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine head IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in trans-Golgi network transport vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    neurogranin
    Names
    neurogranin (protein kinase C substrate, RC3)
    ng
    protein kinase C substrate 7.5 kDa protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024140.3NP_077054.1  neurogranin

      See identical proteins and their annotated locations for NP_077054.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q04940
      UniProtKB/TrEMBL
      A0A8L2UIU9
      Related
      ENSRNOP00000014404.4, ENSRNOT00000014404.5
      Conserved Domains (1) summary
      smart00015
      Location:3247
      IQ; Calmodulin-binding motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      45444223..45452417 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)