Thtpa thiamine triphosphatase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Thtpaprovided by RGD
Official Full Name: thiamine triphosphataseprovided by RGD
Primary source: RGD:727917
See related: EnsemblRapid:ENSRNOG00000018105 AllianceGenome:RGD:727917
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable magnesium ion binding activity and thiamine triphosphate phosphatase activity. Predicted to be involved in dephosphorylation and thiamine diphosphate biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human THTPA (thiamine triphosphatase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 166.2), Kidney (RPKM 72.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p13

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (32536297..32541537)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (28567619..28571580)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (33755157..33759117)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

RH131652 (e-PCR)
- UniSTS:214935

AI715271 (e-PCR)
- UniSTS:245956

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables magnesium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables thiamine triphosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thiamine triphosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables thiamine triphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables thiamine triphosphate phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in thiamine diphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in thiamine diphosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in thiamine diphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in thiamine diphosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in thiamine diphosphate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in thiamine metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: thiamine-triphosphatase

Names: thTPase

NP_001007683.1

EC 3.6.1.28

XP_006252032.1

EC 3.6.1.28

XP_063130321.1

EC 3.6.1.28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.