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    Arhgef15 Rho guanine nucleotide exchange factor 15 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287418, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Arhgef15provided by RGD
    Official Full Name
    Rho guanine nucleotide exchange factor 15provided by RGD
    Primary source
    RGD:1306961
    See related
    EnsemblRapid:ENSRNOG00000004566 AllianceGenome:RGD:1306961
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    E5
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in positive regulation of stress fiber assembly and regulation of catalytic activity. Located in cytoplasm. Orthologous to human ARHGEF15 (Rho guanine nucleotide exchange factor 15). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 69.9), Kidney (RPKM 61.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgef15 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (54149372..54162128, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (53650521..53663269, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (55532097..55545675, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene outer dense fiber of sperm tails 4 Neighboring gene ribosomal protein S4, X-linked, pseudogene 7 Neighboring gene uncharacterized LOC134480814 Neighboring gene solute carrier family 25, member 35 Neighboring gene RAN guanine nucleotide release factor Neighboring gene phosphoribosylformylglycinamidine synthase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells. Ogita H, et al. Circ Res, 2003 Jul 11. PMID 12775584
    2. EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation. Margolis SS, et al. Cell, 2010 Oct 29. PMID 21029865, Free PMC Article
    3. Genome-wide identification of endothelial cell-enriched genes in the mouse embryo. Takase H, et al. Blood, 2012 Jul 26. PMID 22535667
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of synapse maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of stress fiber assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of catalytic activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within retina vasculature morphogenesis in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 15
    Names
    Rho guanine nucleotide exchange factor (GEF) 15
    ephexin-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414295.2 → NP_001401224.1  rho guanine nucleotide exchange factor 15

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2JTU0
      Related
      ENSRNOP00000068844.1, ENSRNOT00000084385.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      54149372..54162128 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085436.2 → XP_038941364.1  rho guanine nucleotide exchange factor 15 isoform X1

      Conserved Domains (2) summary
      smart00325
      Location:390 → 566
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:590 → 710
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain

    RNA

    1. XR_005489733.2 RNA Sequence

    2. XR_005489734.2 RNA Sequence

      Related
      ENSRNOT00000162011.1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
    Molecular Biology Databases
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