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    Atn1 atrophin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29515, updated on 9-Dec-2024

    Summary

    Symbol
    Atn1provided by RGD
    Full Name
    atrophin 1provided by RGD
    Primary source
    RGD:61832
    See related
    EnsemblRapid:ENSRNOG00000060594 AllianceGenome:RGD:61832
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Drpla
    Summary
    Enables JUN kinase binding activity. Involved in regulation of neuron differentiation. Located in cell leading edge; nucleus; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in dentatorubral-pallidoluysian atrophy and schizophrenia. Orthologous to human ATN1 (atrophin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 31.3), Adrenal (RPKM 28.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Atn1 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159240573..159254378, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157554287..157568092, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157267394..157281199, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, non-receptor type 6 Neighboring gene U7 small nuclear RNA Neighboring gene gene rich cluster, C10 gene Neighboring gene uncharacterized LOC120102384 Neighboring gene enolase 2 Neighboring gene leucine rich repeat containing 23 Neighboring gene uncharacterized LOC134486638

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables JUN kinase binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cell killing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell killing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in determination of adult lifespan IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within determination of adult lifespan ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in maintenance of cell polarity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in maintenance of cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within male gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to food IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to food ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    atrophin-1
    Names
    atrophin-1-like
    dentatorubral pallidoluysian atrophy
    dentatorubral-pallidoluysian atrophy protein homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394346.1NP_001381275.1  atrophin-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      P54258
      UniProtKB/TrEMBL
      A0A0G2JZ81, A6ILJ9
      Conserved Domains (1) summary
      pfam03154
      Location:11183
      Atrophin-1; Atrophin-1 family
    2. NM_017228.3NP_058924.2  atrophin-1

      See identical proteins and their annotated locations for NP_058924.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      P54258
      UniProtKB/TrEMBL
      A0A0G2JZ81, A6ILJ9
      Related
      ENSRNOP00000070945.2, ENSRNOT00000088895.3
      Conserved Domains (1) summary
      pfam03154
      Location:11183
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      159240573..159254378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)