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    Ttbk1 tau tubulin kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316229, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ttbk1provided by RGD
    Official Full Name
    tau tubulin kinase 1provided by RGD
    Primary source
    RGD:1559518
    See related
    EnsemblRapid:ENSRNOG00000018416 AllianceGenome:RGD:1559518
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1559518
    Summary
    Predicted to enable protein kinase activity and tau protein binding activity. Predicted to be involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of microglial cell activation; and protein phosphorylation. Predicted to be located in several cellular components, including neuronal cell body; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human TTBK1 (tau tubulin kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 66.4) and Brain (RPKM 42.0) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ttbk1 in Genome Data Viewer
    Location:
    9q12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (21990973..22035961)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (14493166..14538372)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (16862305..16899399)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene cullin 9 Neighboring gene 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Neighboring gene solute carrier family 22 member 7 Neighboring gene cysteine-rich protein 3 Neighboring gene zinc finger protein 318 Neighboring gene small nucleolar RNA, H/ACA box 38

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation. Sato S, et al. J Neurochem, 2006 Sep. PMID 16923168
    2. Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. Sato S, et al. J Neurosci, 2008 Dec 31. PMID 19118186, Free PMC Article
    3. TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation. Watanabe T, et al. J Cell Biol, 2015 Aug 31. PMID 26323690, Free PMC Article
    4. Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis. Chen S, et al. Neurochem Res, 2012 Dec. PMID 22926577
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tau protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tau-protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in learning or memory ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of microglial cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in substantia nigra development ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tau-tubulin kinase 1
    NP_001258159.1
    XP_038939445.1
    XP_038939446.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271230.2 → NP_001258159.1  tau-tubulin kinase 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2JTK1, D3ZAU7
      Related
      ENSRNOP00000068742.2, ENSRNOT00000080104.3
      Conserved Domains (2) summary
      PHA03307
      Location:962 → 1304
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14130
      Location:33 → 294
      STKc_TTBK1; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      21990973..22035961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083518.2 → XP_038939446.1  tau-tubulin kinase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQS3, D3ZAU7
      Conserved Domains (2) summary
      PHA03307
      Location:1055 → 1397
      PHA03307; transcriptional regulator ICP4; Provisional
      cl21453
      Location:33 → 294
      PKc_like; Protein Kinases, catalytic domain

    2. XM_039083517.2 → XP_038939445.1  tau-tubulin kinase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQS3, D3ZAU7
      Related
      ENSRNOP00000080469.1, ENSRNOT00000116823.2
      Conserved Domains (2) summary
      PHA03307
      Location:1055 → 1397
      PHA03307; transcriptional regulator ICP4; Provisional
      cl21453
      Location:33 → 294
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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