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    Tspan8 tetraspanin 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171048, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tspan8provided by RGD
    Official Full Name
    tetraspanin 8provided by RGD
    Primary source
    RGD:621783
    See related
    EnsemblRapid:ENSRNOG00000004411 AllianceGenome:RGD:621783
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CO-29; Tm4sf3
    Summary
    Enables integrin binding activity. Involved in negative regulation of blood coagulation. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Orthologous to human TSPAN8 (tetraspanin 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 897.0), Muscle (RPKM 556.5) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tspan8 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (53331019..53365402)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (51444946..51479360)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (58814805..58847564)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL19-like Neighboring gene uncharacterized LOC134479871 Neighboring gene uncharacterized LOC134479873 Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC102551386 Neighboring gene uncharacterized LOC134479872 Neighboring gene uncharacterized LOC102551482

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of blood coagulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    tetraspanin-8
    Names
    D6.1A
    transmembrane 4 superfamily member 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133526.2NP_598210.1  tetraspanin-8

      See identical proteins and their annotated locations for NP_598210.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I5Y9E0, A6IGL6, A6IGL8, O55158
      Conserved Domains (2) summary
      cd03154
      Location:106204
      TM4SF3_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:8228
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      53331019..53365402
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078341.2XP_038934269.1  tetraspanin-8 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y9E0, A6IGL6, A6IGL8, O55158
      Related
      ENSRNOP00000005909.4, ENSRNOT00000005909.8
      Conserved Domains (2) summary
      cd03154
      Location:106204
      TM4SF3_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:8228
      Tetraspannin; Tetraspanin family