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    Rasal1 RAS protein activator like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360814, updated on 2-Nov-2024

    Summary

    Official Symbol
    Rasal1provided by RGD
    Official Full Name
    RAS protein activator like 1provided by RGD
    Primary source
    RGD:1311820
    See related
    EnsemblRapid:ENSRNOG00000001374 AllianceGenome:RGD:1311820
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in positive regulation of dendrite extension. Predicted to be located in cytosol and plasma membrane. Orthologous to human RASAL1 (RAS protein activator like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 63.8), Adrenal (RPKM 56.7) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rasal1 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (41541865..41574957, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (35881269..35913727, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (41416218..41449445, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene 2'-5' oligoadenylate synthetase 2 Neighboring gene deltex E3 ubiquitin ligase 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit A1, pseudogene 2 Neighboring gene cilia and flagella associated protein 73 Neighboring gene DEAD-box helicase 54

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rasGAP-activating-like protein 1
    Names
    RAS protein activator like 1 (GAP1 like)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108335.1NP_001101805.1  rasGAP-activating-like protein 1

      See identical proteins and their annotated locations for NP_001101805.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473973
      UniProtKB/TrEMBL
      A6J1I2, D3ZHY9
      Related
      ENSRNOP00000001856.6, ENSRNOT00000001856.8
      Conserved Domains (6) summary
      cd05135
      Location:262548
      RasGAP_RASAL; Ras-GTPase Activating Domain of RASAL1 and similar proteins
      smart00323
      Location:242604
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam00169
      Location:566672
      PH; PH domain
      pfam00779
      Location:681708
      BTK; BTK motif
      cl14603
      Location:6126
      C2; C2 domain
      cl17171
      Location:552689
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      41541865..41574957 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249395.5XP_006249457.1  rasGAP-activating-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006249457.1

      UniProtKB/TrEMBL
      A6J1I2, D3ZHY9
      Conserved Domains (6) summary
      cd05135
      Location:262548
      RasGAP_RASAL; Ras-GTPase Activating Domain of RASAL1 and similar proteins
      smart00323
      Location:242604
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam00169
      Location:566672
      PH; PH domain
      pfam00779
      Location:681708
      BTK; BTK motif
      cl14603
      Location:6126
      C2; C2 domain
      cl17171
      Location:552689
      PH-like; Pleckstrin homology-like domain
    2. XM_017598399.3XP_017453888.1  rasGAP-activating-like protein 1 isoform X3

      Conserved Domains (6) summary
      cd05135
      Location:80366
      RasGAP_RASAL; Ras-GTPase Activating Domain of RASAL1 and similar proteins
      smart00323
      Location:60422
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam00169
      Location:384490
      PH; PH domain
      pfam00779
      Location:499526
      BTK; BTK motif
      cl14603
      Location:3372
      C2; C2 domain
      cl17171
      Location:370507
      PH-like; Pleckstrin homology-like domain
    3. XM_039089599.2XP_038945527.1  rasGAP-activating-like protein 1 isoform X2

      Conserved Domains (3) summary
      pfam00779
      Location:323350
      BTK; BTK motif
      cl02569
      Location:1190
      RasGAP; Ras GTPase Activating Domain
      cl17171
      Location:194331
      PH-like; Pleckstrin homology-like domain