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    E2f7 E2F transcription factor 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314818, updated on 27-Nov-2024

    Summary

    Official Symbol
    E2f7provided by RGD
    Official Full Name
    E2F transcription factor 7provided by RGD
    Primary source
    RGD:1310258
    See related
    EnsemblRapid:ENSRNOG00000026252 AllianceGenome:RGD:1310258
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    E2F-7
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in several processes, including hepatocyte differentiation; regulation of cell cycle process; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of cell population proliferation and regulation of DNA-templated transcription. Predicted to be located in nuclear speck. Predicted to be part of RNA polymerase II transcription regulator complex. Orthologous to human E2F7 (E2F transcription factor 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 72.5), Spleen (RPKM 21.9) and 7 other tissues See more
    Orthologs
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    Genomic context

    See E2f7 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (48036881..48079055)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (46150533..46192739)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (53275659..53318261)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene Histone deacetylase 1, pseudogene 6 Neighboring gene uncharacterized LOC120093801 Neighboring gene neuron navigator 3 Neighboring gene uncharacterized LOC134479685 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription repressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription repressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chorionic trophoblast cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chorionic trophoblast cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chorionic trophoblast cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hepatocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hepatocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hepatocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of G1/S transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cytokinesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in placenta development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in placenta development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA endoreduplication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA endoreduplication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA endoreduplication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in trophoblast giant cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in trophoblast giant cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in trophoblast giant cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108092.2NP_001101562.2  transcription factor E2F7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      D4A4D7
      UniProtKB/TrEMBL
      A0A0A0MY02
      Conserved Domains (1) summary
      pfam02319
      Location:145212
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      48036881..48079055
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241321.4XP_006241383.1  transcription factor E2F7 isoform X1

      See identical proteins and their annotated locations for XP_006241383.1

      UniProtKB/Swiss-Prot
      D4A4D7
      UniProtKB/TrEMBL
      A0A0A0MY02
      Related
      ENSRNOP00000081093.1, ENSRNOT00000104778.2
      Conserved Domains (1) summary
      pfam02319
      Location:145212
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain