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    Ngdn neuroguidin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305887, updated on 3-Dec-2024

    Summary

    Official Symbol
    Ngdnprovided by RGD
    Official Full Name
    neuroguidinprovided by RGD
    Primary source
    RGD:1310211
    See related
    EnsemblRapid:ENSRNOG00000018069 AllianceGenome:RGD:1310211
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310211
    Summary
    Involved in negative regulation of protein localization to plasma membrane; postsynaptic modulation of chemical synaptic transmission; and regulation of translation at postsynapse. Is active in glutamatergic synapse; perforant pathway to dendrate granule cell synapse; and postsynapse. Orthologous to human NGDN (neuroguidin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 93.7), Thymus (RPKM 92.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ngdn in Genome Data Viewer
    Location:
    15p13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (32459898..32467260)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (28489950..28497286)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (33677333..33684840)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096985 Neighboring gene uncharacterized LOC120096984 Neighboring gene microRNA 208b Neighboring gene myosin heavy chain 7 Neighboring gene uncharacterized LOC134482119 Neighboring gene zinc finger homeobox 2 Neighboring gene thiamine triphosphatase Neighboring gene adaptor related protein complex 1 subunit gamma 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in filopodium IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in perforant pathway to dendrate granule cell synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in perforant pathway to dendrate granule cell synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    neuroguidin
    Names
    neuroguidin, EIF4E binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107263.1NP_001100733.1  neuroguidin

      See identical proteins and their annotated locations for NP_001100733.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474049
      UniProtKB/TrEMBL
      A0A8I6ALQ0, A6KGY5
      Related
      ENSRNOP00000094474.2, ENSRNOT00000094340.2
      Conserved Domains (1) summary
      pfam04000
      Location:1897
      Sas10_Utp3; Sas10/Utp3/C1D family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      32459898..32467260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274248.1XP_063130318.1  neuroguidin isoform X1

      UniProtKB/TrEMBL
      A0A8I6ALQ0
    2. XM_063274249.1XP_063130319.1  neuroguidin isoform X2

      UniProtKB/TrEMBL
      A0A8I6ALQ0
      Related
      ENSRNOP00000024337.6, ENSRNOT00000024337.6