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    Cpne6 copine 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691478, updated on 3-Dec-2024

    Summary

    Official Symbol
    Cpne6provided by RGD
    Official Full Name
    copine 6provided by RGD
    Primary source
    RGD:1583895
    See related
    EnsemblRapid:ENSRNOG00000018399 AllianceGenome:RGD:1583895
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium-dependent phospholipid binding activity and phosphatidylserine binding activity. Predicted to be involved in cellular response to calcium ion; positive regulation of dendrite extension; and postsynaptic actin cytoskeleton organization. Predicted to be located in several cellular components, including axon; clathrin-coated endocytic vesicle; and dendrite. Predicted to be active in plasma membrane. Orthologous to human CPNE6 (copine 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 138.5) See more
    Orthologs
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    Genomic context

    See Cpne6 in Genome Data Viewer
    Location:
    15p13
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (32968047..32975008)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (28998293..29005044)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34187229..34194107)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene dehydrogenase/reductase 4 Neighboring gene capping protein regulator and myosin 1 linker 3 Neighboring gene uncharacterized LOC102552093 Neighboring gene uncharacterized LOC120096988 Neighboring gene neural retina leucine zipper Neighboring gene phosphoenolpyruvate carboxykinase 2 (mitochondrial)

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to calcium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in postsynaptic actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    copine-6
    Names
    copine VI (neuronal)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191113.2NP_001178042.2  copine-6

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6KH05, D4ACG7, H1UBM5
      Related
      ENSRNOP00000024978.5, ENSRNOT00000024978.8
      Conserved Domains (3) summary
      cd04047
      Location:152266
      C2B_Copine; C2 domain second repeat in Copine
      cd04048
      Location:20137
      C2A_Copine; C2 domain first repeat in Copine
      pfam07002
      Location:325541
      Copine

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      32968047..32975008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274663.1XP_063130733.1  copine-6 isoform X1

      UniProtKB/TrEMBL
      A6KH05, D4ACG7, H1UBM5