Slc22a3 solute carrier family 22 member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc22a3provided by RGD
Official Full Name: solute carrier family 22 member 3provided by RGD
Primary source: RGD:3701
See related: EnsemblRapid:ENSRNOG00000022946 AllianceGenome:RGD:3701
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: EMT; OCT3
Summary: Enables several functions, including dopamine:sodium symporter activity; organic cation transmembrane transporter activity; and toxin transmembrane transporter activity. Involved in several processes, including histamine transport; monoamine transport; and spermidine transport. Located in apical plasma membrane; endomembrane system; and mitochondrial membrane. Orthologous to human SLC22A3 (solute carrier family 22 member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 72.3), Heart (RPKM 35.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (50783218..50872358)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (48235476..48324617)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (48433079..48521261)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study is the first to examine the subcellular localization of organic cation transporter 3 (OCT3) in any tissue, and the first to explore its spatial relationship to synaptic structures in the brain. Study suggests that OCT3 not only contributes to the clearance of extracellular monoamines, but also plays a role in their intracellular disposition and action.
Title: Organic cation transporter 3 (OCT3) is localized to intracellular and surface membranes in select glial and neuronal cells within the basolateral amygdaloid complex of both rats and mice.

Submit: New GeneRIF Correction

General gene information

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Markers

RH132315 (e-PCR)
- UniSTS:215598

AU049521 (e-PCR)
- UniSTS:145968

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dopamine:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables monoamine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables monoamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables neurotransmitter transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables neurotransmitter transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic anion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic cation transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables organic cation transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic cation transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables quaternary ammonium group transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables quaternary ammonium group transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables spermidine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables toxin transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables toxin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular detoxification	ISO Inferred from Sequence Orthology more info
involved_in dopamine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in dopamine transport	ISO Inferred from Sequence Orthology more info
involved_in dopamine uptake	ISO Inferred from Sequence Orthology more info
involved_in epinephrine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in epinephrine transport	ISO Inferred from Sequence Orthology more info
involved_in epinephrine uptake	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in histamine transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within histamine transport	ISO Inferred from Sequence Orthology more info
involved_in histamine transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within histamine uptake	ISO Inferred from Sequence Orthology more info
involved_in histamine uptake	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoamine transport	ISO Inferred from Sequence Orthology more info
involved_in monoamine transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monocarboxylic acid transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neurotransmitter transport	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter transport	ISO Inferred from Sequence Orthology more info
involved_in norepinephrine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in norepinephrine transport	ISO Inferred from Sequence Orthology more info
involved_in norepinephrine uptake	ISO Inferred from Sequence Orthology more info
involved_in organic anion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in organic cation transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in organic cation transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within organic cation transport	ISO Inferred from Sequence Orthology more info
involved_in organic cation transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within organic hydroxy compound transport	ISO Inferred from Sequence Orthology more info
involved_in quaternary ammonium group transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within quaternary ammonium group transport	ISO Inferred from Sequence Orthology more info
involved_in quaternary ammonium group transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of appetite	ISO Inferred from Sequence Orthology more info
involved_in serotonin transport	IDA Inferred from Direct Assay more info	PubMed
involved_in serotonin transport	ISO Inferred from Sequence Orthology more info
involved_in serotonin uptake	ISO Inferred from Sequence Orthology more info
involved_in spermidine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in spermidine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endomembrane system	IDA Inferred from Direct Assay more info	PubMed
located_in endomembrane system	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nuclear outer membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier family 22 member 3

Names: extraneuronal monoamine transporter; organic cation transporter 3; solute carrier family 22 (extraneuronal monoamine transporter), member 3; solute carrier family 22 (organic cation transporter), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019230.1 → NP_062103.1 solute carrier family 22 member 3

See identical proteins and their annotated locations for NP_062103.1

Status: PROVISIONAL

Source sequence(s)

AF055286

UniProtKB/Swiss-Prot

O88446

UniProtKB/TrEMBL

A6KJX6

Related

ENSRNOP00000029748.2, ENSRNOT00000037369.4

Conserved Domains (2) summary

cd06174
Location:145 → 513

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00898
Location:12 → 523

2A0119; cation transport protein