Rpusd4 RNA pseudouridylate synthase domain containing 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rpusd4provided by MGI
Official Full Name: RNA pseudouridylate synthase domain containing 4provided by MGI
Primary source: MGI:MGI:1919239
See related: Ensembl:ENSMUSG00000032044 AllianceGenome:MGI:1919239
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2410001E19Rik
Summary: Predicted to enable mitochondrial ribosomal large subunit rRNA binding activity; pseudouridine synthase activity; and tRNA binding activity. Predicted to be involved in mRNA pseudouridine synthesis; mitochondrial tRNA pseudouridine synthesis; and positive regulation of mitochondrial translation. Located in mitochondrion. Is expressed in genitourinary system. Orthologous to human RPUSD4 (RNA pseudouridine synthase D4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 8.8), limb E14.5 (RPKM 7.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A4; 9 20.15 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (35179177..35187253)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (35267881..35275957)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C76578 (e-PCR)
- UniSTS:159859

RH125999 (e-PCR)
- UniSTS:162711

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mitochondrial ribosomal large subunit rRNA binding	IEA Inferred from Electronic Annotation more info
enables mitochondrial ribosomal large subunit rRNA binding	ISO Inferred from Sequence Orthology more info
enables pseudouridine synthase activity	ISO Inferred from Sequence Orthology more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info
enables tRNA binding	ISO Inferred from Sequence Orthology more info
enables tRNA pseudouridine synthase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA pseudouridine synthesis	IEA Inferred from Electronic Annotation more info
involved_in mRNA pseudouridine synthesis	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial tRNA pseudouridine synthesis	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial tRNA pseudouridine synthesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in rRNA pseudouridine synthesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in ribonucleoprotein granule	IEA Inferred from Electronic Annotation more info
located_in ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pseudouridylate synthase RPUSD4, mitochondrial

Names: RNA pseudouridylate synthase domain-containing protein 4; mitochondrial RNA pseudouridine synthase Rpusd4

NP_082316.1

EC 5.4.99.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028040.2 → NP_082316.1 pseudouridylate synthase RPUSD4, mitochondrial

See identical proteins and their annotated locations for NP_082316.1

Status: PROVISIONAL

Source sequence(s)

BC061256

Consensus CDS

CCDS22962.1

UniProtKB/Swiss-Prot

Q9CWX4

Related

ENSMUSP00000034543.5, ENSMUST00000034543.5

Conserved Domains (2) summary

TIGR00005
Location:46 → 347

rluA_subfam; pseudouridine synthase, RluA family

cd02869
Location:106 → 329

PseudoU_synth_RluCD_like; Pseudouridine synthase, RsuA/RluD family