Mrm3 mitochondrial rRNA methyltransferase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mrm3provided by MGI
Official Full Name: mitochondrial rRNA methyltransferase 3provided by MGI
Primary source: MGI:MGI:1914640
See related: Ensembl:ENSMUSG00000038046 AllianceGenome:MGI:1914640
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HC90; Rnmtl1; 4833420N02Rik
Summary: Predicted to enable identical protein binding activity and rRNA (guanosine-2'-O-)-methyltransferase activity. Predicted to be involved in rRNA 2'-O-methylation. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; egg cylinder; genitourinary system; and hemolymphoid system. Orthologous to human MRM3 (mitochondrial rRNA methyltransferase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver E14 (RPKM 6.1), liver E14.5 (RPKM 5.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 45.92 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (76134562..76141451)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (76243736..76250625)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNMTL1, MRM1, and MRM2 (FtsJ2) as members of the RNA methyltransferase family that may be responsible for the three known 2'-O-ribose modifications of the 16 S rRNA core of the large mitochondrial ribosome subunit.
Title: Mitochondrial ribosomal RNA (rRNA) methyltransferase family members are positioned to modify nascent rRNA in foci near the mitochondrial DNA nucleoid.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables rRNA (guanosine-2'-O-)-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables rRNA (guanosine-2'-O-)-methyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in rRNA 2'-O-methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rRNA methyltransferase 3, mitochondrial

Names: 16S rRNA (guanosine(1370)-2'-O)-methyltransferase; 16S rRNA [Gm1370] 2'-O-methyltransferase; RNA methyltransferase like 1; RNA methyltransferase-like protein 1

NP_899086.2

EC 2.1.1.-

XP_030102108.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_183263.5 → NP_899086.2 rRNA methyltransferase 3, mitochondrial

See identical proteins and their annotated locations for NP_899086.2

Status: VALIDATED

Source sequence(s)

AK014739, AK132643, BC090975

Consensus CDS

CCDS48852.1

UniProtKB/Swiss-Prot

A4FUR4, Q3UGQ7, Q5ND52, Q5U5W2, Q8C1J9

Related

ENSMUSP00000042882.5, ENSMUST00000040577.5

Conserved Domains (3) summary

smart00967
Location:125 → 191

SpoU_sub_bind; RNA 2'-O ribose methyltransferase substrate binding

COG0566
Location:117 → 407

SpoU; tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]

pfam00588
Location:209 → 398

SpoU_methylase; SpoU rRNA Methylase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

76134562..76141451

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246248.1 → XP_030102108.1 rRNA methyltransferase 3, mitochondrial isoform X1

Conserved Domains (1) summary

cd18106
Location:14 → 204

SpoU-like_RNMTL1; SAM-dependent rRNA methylase related to RNMTL1