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    Zfp74 zinc finger protein 74 [ Mus musculus (house mouse) ]

    Gene ID: 72723, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Zfp74provided by MGI
    Official Full Name
    zinc finger protein 74provided by MGI
    Primary source
    MGI:MGI:107784
    See related
    Ensembl:ENSMUSG00000059975 AllianceGenome:MGI:107784
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KRAB8; Zfp66; Znf569; mszf21; mszf77; zfp-74; 2810054M15Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in cerebral cortex ventricular layer; cortical plate; early conceptus; oocyte; and ureter. Orthologous to human ZNF569 (zinc finger protein 569). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 4.0), CNS E14 (RPKM 3.2) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp74 in Genome Data Viewer
    Location:
    7 B1; 7 17.26 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29632086..29653579, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (29932661..29954148, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 27 Neighboring gene STARR-positive B cell enhancer ABC_E9288 Neighboring gene microRNA 7668 Neighboring gene zinc finger protein 383 Neighboring gene STARR-seq mESC enhancer starr_18496 Neighboring gene RIKEN cDNA C230062I16 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:30738577-30738760 Neighboring gene STARR-positive B cell enhancer ABC_E8160 Neighboring gene predicted gene, 57504 Neighboring gene macrophage migration inhibitory factor, pseudogene Neighboring gene predicted gene, 31735 Neighboring gene STARR-seq mESC enhancer starr_18498

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia. Ihle JN, et al. J Virol, 1989 Jul. PMID 2542606, Free PMC Article
    2. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479878, Free PMC Article
    3. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
    4. Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci. Marine JC, et al. Mamm Genome, 1996 Jun. PMID 8662221
    5. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 569

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178384.4 → NP_848471.2  zinc finger protein 569

      Status: VALIDATED

      Source sequence(s)
      AC149283
      Consensus CDS
      CCDS39874.1
      UniProtKB/Swiss-Prot
      E9QK35, O88237, Q80W31
      Related
      ENSMUSP00000103840.2, ENSMUST00000108205.9
      Conserved Domains (4) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:205 → 638
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:433 → 453
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:641 → 666
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      29632086..29653579 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540385.5 → XP_006540448.1  zinc finger protein 569 isoform X1

      UniProtKB/Swiss-Prot
      E9QK35, O88237, Q80W31
      Related
      ENSMUSP00000032797.9, ENSMUST00000032797.9
      Conserved Domains (4) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:205 → 638
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:433 → 453
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:641 → 666
      zf-H2C2_2; Zinc-finger double domain

    2. XM_011250720.4 → XP_011249022.1  zinc finger protein 569 isoform X1

      UniProtKB/Swiss-Prot
      E9QK35, O88237, Q80W31
      Conserved Domains (4) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:205 → 638
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:433 → 453
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:641 → 666
      zf-H2C2_2; Zinc-finger double domain

    3. XM_036153463.1 → XP_036009356.1  zinc finger protein 569 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:79 → 512
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:307 → 327
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:515 → 540
      zf-H2C2_2; Zinc-finger double domain

    4. XM_030243015.2 → XP_030098875.1  zinc finger protein 569 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:79 → 512
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:307 → 327
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:515 → 540
      zf-H2C2_2; Zinc-finger double domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001357888.1: Suppressed sequence

      Description
      NM_001357888.1: This RefSeq was removed because it was redundant with an existing RefSeq which alignment software didn''t properly align to the reference genome.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80W31.2 GenPept UniProtKB/Swiss-Prot:Q80W31

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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