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    LAS1 rRNA-processing protein LAS1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853937, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LAS1
    Official Full Name
    rRNA-processing protein LAS1
    Primary source
    SGD:S000001771
    Locus tag
    YKR063C
    See related
    AllianceGenome:SGD:S000001771; FungiDB:YKR063C; VEuPathDB:YKR063C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables endonuclease activity. Involved in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in cytoplasm and nucleolus. Part of preribosome, large subunit precursor. Used to study Wilson-Turner syndrome. Human ortholog(s) of this gene implicated in Wilson-Turner syndrome. Orthologous to human LAS1L (LAS1 like ribosome biogenesis factor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LAS1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (560789..562297, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene transcription factor TFIIE subunit TFA2 Neighboring gene Oaf3p Neighboring gene Pam17p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. It takes two (Las1 HEPN endoribonuclease domains) to cut RNA correctly. Pillon MC, et al. J Biol Chem, 2020 May 1. PMID 32220933, Free PMC Article
    2. Characterization of the molecular crosstalk within the essential Grc3/Las1 pre-rRNA processing complex. Pillon MC, et al. RNA, 2018 May. PMID 29440475, Free PMC Article
    3. Grc3 programs the essential endoribonuclease Las1 for specific RNA cleavage. Pillon MC, et al. Proc Natl Acad Sci U S A, 2017 Jul 11. PMID 28652339, Free PMC Article
    4. Structural and mechanistic insights into ribosomal ITS2 RNA processing by nuclease-kinase machinery. Chen J, et al. Elife, 2024 Jan 5. PMID 38180340, Free PMC Article
    5. LAS1 is an essential nuclear protein involved in cell morphogenesis and cell surface growth. Doseff AI, et al. Genetics, 1995 Nov. PMID 8582632, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of 5.8S rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of 5.8S rRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of LSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of LSU-rRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Las1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rRNA-processing protein LAS1
    NP_012989.3
    • Endonuclease involved in pre-rRNA processing at both ends of ITS2; functions with Grc3p in a conserved mechanism to cleave pre-rRNA at a specific site during rRNA processing and ribosome biogenesis; may coordinate the action of the Rat1p-Rai1p exoRNAse; required for the G1/S cell cycle transition; human ortholog is Las1L; mutants require the SSD1-v allele for viability

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      560789..562297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179853.3 → NP_012989.3  TPA: rRNA-processing protein LAS1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012989.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXC4, P36146, Q66R55
      UniProtKB/TrEMBL
      B5VML0, C8ZCM6, N1P0J1
      Conserved Domains (1) summary
      pfam04031
      Location:7 → 161
      Las1; Las1-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36146.1

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