VPS1 dynamin-like GTPase VPS1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: VPS1
Official Full Name: dynamin-like GTPase VPS1
Primary source: SGD:S000001709
Locus tag: YKR001C
See related: AllianceGenome:SGD:S000001709; FungiDB:YKR001C; VEuPathDB:YKR001C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: GRD1; LAM1; SPO15; VPL1; VPT26
Summary: Enables GTPase activity and actin filament binding activity. Involved in several processes, including peroxisome fission; protein localization to organelle; and protein localization to phagophore assembly site. Located in several cellular components, including actin cortical patch; fungal-type vacuole membrane; and late endosome. Is active in phagophore assembly site. Used to study several diseases, including Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; developmental and epileptic encephalopathy; lethal congenital contracture syndrome; and microcytic anemia. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease dominant intermediate B; alopecia areata; avian influenza; centronuclear myopathy 1; and developmental and epileptic encephalopathy (multiple). Orthologous to several human genes including MX1 (MX dynamin like GTPase 1); MX2 (MX dynamin like GTPase 2); and DNM1 (dynamin 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See VPS1 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (440608..442722, complement)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The dynamin Vps1 mediates Atg9 transport to the sites of autophagosome formation.
Title: The dynamin Vps1 mediates Atg9 transport to the sites of autophagosome formation.
The present study demonstrates that Vps1 plays a role in later stages of the endosome-to-the trans-Golgi Network traffic.
Title: Yeast dynamin and Ypt6 function in parallel for the endosome-to-Golgi retrieval of Snc1.
Structures of the fungal dynamin-related protein Vps1 reveal a unique, open helical architecture.
Title: Structures of the fungal dynamin-related protein Vps1 reveal a unique, open helical architecture.
The replacement of these residues led to severe defects in endosome-to-TGN transport of Snc1, providing evidence of the physiological relevance of the interaction of Vps51 with Vps1 for the traffic. Furthermore, our functional analysis revealed that Vps1 acts upstream of Vps51 and that the absence of Vps1 resulted in reduced localization levels of Vps51 and its binding partner Tlg1 to the late Golgi.
Title: Yeast dynamin associates with the GARP tethering complex for endosome-to-Golgi traffic.
These data support a model in which phosphorylation and dephosphorylation of Vps1 promote distinct interactions and highlight the importance of such regulatory events in facilitating sequential progression of the endocytic process.
Title: Phosphorylation Regulates the Endocytic Function of the Yeast Dynamin-Related Protein Vps1.
A model is proposed in which actin filaments bind Vps1 during invagination, and this interaction is important to transduce the force of actin polymerization to the membrane to drive successful scission.
Title: A dynamin-actin interaction is required for vesicle scission during endocytosis in yeast.
Vps1 functions as a recycling factor in the membrane traffic.
Title: Vps1, a recycling factor for the traffic from early endosome to the late Golgi.
Fission of retromer SNX-BAR-coated tubules from yeast endosomes is promoted by Vps1.
Title: Fission of SNX-BAR-coated endosomal retrograde transport carriers is promoted by the dynamin-related protein Vps1.
Vps1 is required for correct and efficient protein trafficking from the late endosomal compartments to the vacuole.
Title: Vps1 in the late endosome-to-vacuole traffic.
Vps1 and Rvs167 function together to mediate scission during endocytosis in Saccharomyces cerevisiae.
Title: Yeast dynamin Vps1 and amphiphysin Rvs167 function together during endocytosis.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament bundle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular distribution of mitochondria	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid tube assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in peroxisome fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in peroxisome fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome organization	IDA Inferred from Direct Assay more info	PubMed
involved_in peroxisome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to phagophore assembly site	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein retention in Golgi apparatus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to vacuole	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vacuolar transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in actin cortical patch	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
located_in fungal-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
is_active_in phagophore assembly site	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: dynamin-like GTPase VPS1

NP_012926.1

Dynamin-like GTPase required for vacuolar sorting; promotes fission of retrograde transport carriers from endosome; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

440608..442722 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179791.1 → NP_012926.1 TPA: dynamin-like GTPase VPS1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012926.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXT7, P21576

UniProtKB/TrEMBL

A6ZZW6, B3LR85, B5VMF0, C7GQG7, G2WI33, N1P809

Conserved Domains (3) summary

cd08771
Location:27 → 336

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:258 → 541

Dynamin_M; Dynamin central region

pfam02212
Location:616 → 704

GED; Dynamin GTPase effector domain