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    RPC25 DNA-directed RNA polymerase III subunit RPC25 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853713, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPC25
    Official Full Name
    DNA-directed RNA polymerase III subunit RPC25
    Primary source
    SGD:S000001627
    Locus tag
    YKL144C
    See related
    AllianceGenome:SGD:S000001627; FungiDB:YKL144C; VEuPathDB:YKL144C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YKL1
    Summary
    Contributes to RNA polymerase III activity. Involved in tRNA transcription by RNA polymerase III and transcription initiation at RNA polymerase III promoter. Part of RNA polymerase III complex. Orthologous to human POLR3H (RNA polymerase III subunit H). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPC25 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (175843..176481, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Avt3p Neighboring gene proteasome regulatory particle base subunit RPT1 Neighboring gene Ltv1p Neighboring gene Mrp8p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C25, an essential RNA polymerase III subunit related to the RNA polymerase II subunit RPB7. Sadhale PP, et al. Mol Cell Biol, 1994 Sep. PMID 8065349, Free PMC Article
    2. Rpc25, a conserved RNA polymerase III subunit, is critical for transcription initiation. Zaros C, et al. Mol Microbiol, 2005 Jan. PMID 15612920
    3. Molecular cloning and physical analysis of an 8.2 kb segment of chromosome XI of Saccharomyces cerevisiae reveals five tightly linked genes. Abraham PR, et al. Yeast, 1992 Mar. PMID 1574929
    4. An Rpb4/Rpb7-like complex in yeast RNA polymerase III contains the orthologue of mammalian CGRP-RCP. Siaut M, et al. Mol Cell Biol, 2003 Jan. PMID 12482973, Free PMC Article
    5. Structural biology of RNA polymerase III: subcomplex C17/25 X-ray structure and 11 subunit enzyme model. Jasiak AJ, et al. Mol Cell, 2006 Jul 7. PMID 16818233

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crystal structure of subunit C25 is determined.
      Title: Structural biology of RNA polymerase III: subcomplex C17/25 X-ray structure and 11 subunit enzyme model.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase III activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated transcription initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA transcription by RNA polymerase III IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase III promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at RNA polymerase III promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase III subunit RPC25
    NP_012778.1
    • RNA polymerase III subunit C25; required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      175843..176481 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179710.1 → NP_012778.1  TPA: DNA-directed RNA polymerase III subunit RPC25 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012778.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX52, P35718
      UniProtKB/TrEMBL
      A6ZZH7, B3LQV6, C7GSN9, C8ZC31, G2WHP4, N1P2Y7
      Conserved Domains (1) summary
      TIGR00448
      Location:1 → 184
      rpoE; DNA-directed RNA polymerase (rpoE), archaeal and eukaryotic form
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35718.1

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