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    HMS2 Hms2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853612, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HMS2
    Official Full Name
    Hms2p
    Primary source
    SGD:S000003908
    Locus tag
    YJR147W
    See related
    AllianceGenome:SGD:S000003908; FungiDB:YJR147W; VEuPathDB:YJR147W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in pseudohyphal growth. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HMS2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (704196..705272)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Mgm101p Neighboring gene ribosomal 40S subunit protein S4A Neighboring gene uncharacterized protein Neighboring gene branched-chain-amino-acid transaminase BAT2 Neighboring gene putative nitronate monooxygenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcription mediated insulation and interference direct gene cluster expression switches. Nguyen T, et al. Elife, 2014 Nov 19. PMID 25407679, Free PMC Article
    2. Genomic signatures of adaptation to wine biological ageing conditions in biofilm-forming flor yeasts. Coi AL, et al. Mol Ecol, 2017 Apr. PMID 28192619
    3. Regulators of pseudohyphal differentiation in Saccharomyces cerevisiae identified through multicopy suppressor analysis in ammonium permease mutant strains. Lorenz MC, et al. Genetics, 1998 Dec. PMID 9832522, Free PMC Article
    4. Transcription factor regulation and chromosome dynamics during pseudohyphal growth. Mayhew D, et al. Mol Biol Cell, 2014 Sep 1. PMID 25009286, Free PMC Article
    5. The GET pathway is a major bottleneck for maintaining proteostasis in Saccharomyces cerevisiae. Josefson R, et al. Sci Rep, 2023 Jun 7. PMID 37286562, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in pseudohyphal growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Hms2p
    NP_012681.1
    • Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      704196..705272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181805.1 → NP_012681.1  TPA: Hms2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012681.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWW5, P47175
      UniProtKB/TrEMBL
      C8ZBU7, N1P1C0
      Conserved Domains (1) summary
      COG5169
      Location:1 → 279
      HSF1; Heat shock transcription factor [Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47175.1

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