CDC8 bifunctional thymidylate/uridylate kinase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CDC8
Official Full Name: bifunctional thymidylate/uridylate kinase
Primary source: SGD:S000003818
Locus tag: YJR057W
See related: AllianceGenome:SGD:S000003818; FungiDB:YJR057W; VEuPathDB:YJR057W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables UMP/dUMP kinase activity; nucleoside diphosphate kinase activity; and thymidylate kinase activity. Involved in dTDP biosynthetic process; dTTP biosynthetic process; and dUDP biosynthetic process. Located in cytoplasm and nucleus. Orthologous to human DTYMK (deoxythymidylate kinase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CDC8 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (544062..544712)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables UMP/dUMP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside diphosphate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleoside diphosphate kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables thymidylate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thymidylate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables thymidylate kinase activity	IEA Inferred from Electronic Annotation more info
enables thymidylate kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables thymidylate kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in dTDP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dTDP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dTDP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in dTDP biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dTDP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dTTP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dTTP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dTTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in dTTP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dUDP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dUDP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleoside monophosphate phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: bifunctional thymidylate/uridylate kinase

NP_012591.1

EC 2.7.4.9

Nucleoside monophosphate and nucleoside diphosphate kinase; functions in the de novo biosynthesis of pyrimidine deoxyribonucleotides; thymidylate/uridylate kinase that converts nucleoside monophosphates, dTMP and dUMP to nucleoside diphosphates, dTDP and dUDP; nucleoside diphosphate kinase that converts nucleoside diphosphates, dTDP and dUDP to dTTP and dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe tmp1; human homolog DTYMK can complement the cdc8 null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

544062..544712

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181715.1 → NP_012591.1 TPA: bifunctional thymidylate/uridylate kinase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012591.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWM8, P00572

UniProtKB/TrEMBL

A6ZQ16, B3LQE6, B5VLL1, C7GME6, G2WH62

Conserved Domains (1) summary

cl17190
Location:3 → 206

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...