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    SOP4 Sop4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853247, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SOP4
    Official Full Name
    Sop4p
    Primary source
    SGD:S000003728
    Locus tag
    YJL192C
    See related
    AllianceGenome:SGD:S000003728; FungiDB:YJL192C; VEuPathDB:YJL192C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    EMC7
    Summary
    Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endoplasmic reticulum and membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SOP4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (72710..73414, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene AAA family ATPase CDC6 Neighboring gene uncharacterized protein Neighboring gene ribosomal 40S subunit protein S14B Neighboring gene ribosomal 40S subunit protein S22A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ubiquitous and ancient ER membrane protein complex (EMC): tether or not? Wideman JG. F1000Res, 2015. PMID 26512320, Free PMC Article
    2. An ER membrane protein, Sop4, facilitates ER export of the yeast plasma membrane [H+]ATPase, Pma1. Luo WJ, et al. Traffic, 2002 Oct. PMID 12230471
    3. Structure of the ER membrane complex, a transmembrane-domain insertase. Bai L, et al. Nature, 2020 Aug. PMID 32494008, Free PMC Article
    4. Molecular characterization of propolis-induced cell death in Saccharomyces cerevisiae. de Castro PA, et al. Eukaryot Cell, 2011 Mar. PMID 21193549, Free PMC Article
    5. Evidence for interaction between Hsp90 and the ER membrane complex. Kudze T, et al. Cell Stress Chaperones, 2018 Sep. PMID 29808299, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sop4p
    NP_012343.1
    • ER-membrane protein; subunit of evolutionarily conserved EMC (Endoplasmic Reticulum Membrane Complex) implicated in ERAD (ER-associated degradation) and proper assembly of multi-pass transmembrane (TM) proteins; EMC acts in yeast as an ER-mitochondria tether that interacts with outer membrane protein Tom5 of TOM (Translocase of the Mitochondrial Outer Membrane) complex; suppressor of pma1-7, deletion of SOP4 slows down export of wild-type Pma1p and Pma1-7 from the ER

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      72710..73414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181625.1 → NP_012343.1  TPA: Sop4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012343.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZQE4, D6VVZ9, P39543
      UniProtKB/TrEMBL
      B3LPT5, B5VL00, C8ZB28, G2WGI5, N1P157
      Conserved Domains (1) summary
      pfam17081
      Location:24 → 227
      SOP4; Suppressor of PMA 1-7 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39543.1

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