Hint2 histidine triad nucleotide binding protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hint2provided by MGI
Official Full Name: histidine triad nucleotide binding protein 2provided by MGI
Primary source: MGI:MGI:1916167
See related: Ensembl:ENSMUSG00000028470 AllianceGenome:MGI:1916167
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1190005L05Rik
Summary: Predicted to enable adenosine 5'-monophosphoramidase activity. Acts upstream of or within lipid catabolic process and negative regulation of peptidyl-lysine acetylation. Located in mitochondrion. Is active in mitochondrial matrix. Is expressed in several structures, including brown fat; liver; lung; metanephros; and spleen. Orthologous to human HINT2 (histidine triad nucleotide binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 107.6), liver adult (RPKM 61.1) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 23.05 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (43654227..43656445, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (43654227..43656445, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HINT2 protects against pressure overload-induced cardiac remodelling through mitochondrial pathways.
Title: HINT2 protects against pressure overload-induced cardiac remodelling through mitochondrial pathways.
HINT2 deficiency deteriorates oxidative stress in a mouse model of myocardial infarction.
Title: HINT2 deficiency deteriorates oxidative stress in a mouse model of myocardial infarction.
Protective effect of HINT2 on mitochondrial function via repressing MCU complex activation attenuates cardiac microvascular ischemia-reperfusion injury.
Title: Protective effect of HINT2 on mitochondrial function via repressing MCU complex activation attenuates cardiac microvascular ischemia-reperfusion injury.
Overexpression of the histidine triad nucleotide-binding protein 2 protects cardiac function in the adult mice after acute myocardial infarction.
Title: Overexpression of the histidine triad nucleotide-binding protein 2 protects cardiac function in the adult mice after acute myocardial infarction.
The absence of Hint2 deregulates the posttranslational modification of several mitochondrial proteins, which impedes the adaptation to episodes of nutritional stress.
Title: Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein.
the effect of the mitochondrial protein Hint2 on intracellular Ca(2+) dynamics
Title: Characterization of the effect of the mitochondrial protein Hint2 on intracellular Ca(2+) dynamics.
Hint2/HINT2 positively regulates mitochondrial lipid metabolism and respiration and glucose homeostasis.
Title: Disruption of the histidine triad nucleotide-binding hint2 gene in mice affects glycemic control and mitochondrial function.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables adenosine 5'-monophosphoramidase activity	ISO Inferred from Sequence Orthology more info
enables adenosine 5'-monophosphoramidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of peptidyl-lysine acetylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in steroid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adenosine 5'-monophosphoramidase HINT2

Names: HINT-2; HINT-3; histidine triad nucleotide-binding protein 2, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026871.1 → NP_081147.1 adenosine 5'-monophosphoramidase HINT2 precursor

See identical proteins and their annotated locations for NP_081147.1

Status: PROVISIONAL

Source sequence(s)

BC086940

Consensus CDS

CCDS18106.1

UniProtKB/Swiss-Prot

Q9D0S9

UniProtKB/TrEMBL

Q5M9J2

Related

ENSMUSP00000030192.5, ENSMUST00000030192.5

Conserved Domains (1) summary

cd01276
Location:53 → 155

PKCI_related; Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a ...